Corey Howard E
The Children's Kidney Center of New Jersey, Atlantic Health System, Morristown Memorial Hospital, Morristown, New Jersey 07962, USA.
Kidney Int. 2003 Sep;64(3):777-87. doi: 10.1046/j.1523-1755.2003.00177.x.
The Henderson-Hasselbalch equation and the base excess have been used traditionally to describe the acid-base balance of the blood. In 1981, Stewart proposed a new model of acid-base balance based upon three variables, the "strong ion difference" (SID), the total weak acids (ATot), and the partial pressure of carbon dioxide (Pco2). Over 20 years later, Stewart's physiochemical model still remains largely unknown. In this review, we will present both the traditional and the Stewart models of acid-base balance and then derive each using an "ion equilibrium method." Modern theories of acid-base balance may be useful toward the understanding of complex acid-base disorders.
传统上，亨德森 - 哈塞尔巴尔赫方程和碱剩余用于描述血液的酸碱平衡。1981年，斯图尔特提出了一种基于三个变量的酸碱平衡新模型，即“强离子差”（SID）、总弱酸（ATot）和二氧化碳分压（Pco2）。20多年后，斯图尔特的物理化学模型在很大程度上仍然鲜为人知。在这篇综述中，我们将介绍传统的和斯图尔特的酸碱平衡模型，然后用“离子平衡法”对每个模型进行推导。现代酸碱平衡理论可能有助于理解复杂的酸碱紊乱。
