Tangjitgamol S, Manusirivithaya S, Sheanakul C, Leelahakorn S, Thawaramara T, Jesadapatarakul S
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology and Department of Pathology, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Bangkok, Thailand.
Int J Gynecol Cancer. 2003 Jul-Aug;13(4):558-63. doi: 10.1046/j.1525-1438.2003.13312.x.
Malignant transformation of a dermoid cyst is rare, with squamous cell carcinoma (SCC) being the most common type. During a 10-year period in our institution, we encountered only four cases of SCC out of 425 cases of dermoid cyst, an incidence of 0.94%. Two were of old age, in menopausal status (63 and 74 y), while the other two were in their early forties. Three cases presented with pelvic masses while the other one had nonspecific wasting symptoms and later diarrhea. Three were in early stage and have survived to date without evidence of disease at 8, 12, and 116 months after diagnosis. The other case, in stage III, had suboptimal surgery and responded partially to chemotherapy, subsequently progressed after cessation of the drug, and finally died within a year after diagnosis.
皮样囊肿恶变罕见，其中鳞状细胞癌（SCC）最为常见。在我们机构的10年期间，425例皮样囊肿中仅遇到4例SCC，发病率为0.94%。2例为老年男性，处于绝经状态（63岁和74岁），另外2例为四十出头。3例表现为盆腔肿块，另1例有非特异性消瘦症状，后来出现腹泻。3例处于早期，诊断后分别在8个月、12个月和116个月存活至今，无疾病证据。另一例为III期，手术效果欠佳，对化疗部分反应，停药后病情进展，最终在诊断后一年内死亡。
