Kondo T, Kurokawa H, Fujiwara M, Toyama H, Sakakura K, Ishii J, Nomura M, Yan C, Xu S Q, Hishida H
Department of Radiological Technology, Fujita Health University School of Health Sciences, China.
Chin Med J (Engl). 1992 Oct;105(10):822-7.
This study is to clarify the ability of technetium-99m-Hexakis-2-methoxyisobutyl isonitrile(MIBI) myocardial scintigraphy for assessment of the effect of PTCR/PTCA as compared with conventional thallium-201 myocardial scintigraphy (201Tl). 99mTc-MIBI (740-888MBq) was injected before emergency PTCR/PTCA, and the initial imaging was performed immediately after PTCR/PTCA in 4 patients with acute myocardial infarction (AMI). On the other hand, in 2 patients with old myocardial infarction (OMI), 201Tl and MIBI myocardial imagings were performed before and one week after rescue PTCA. The defect area on the follow-up MIBI imaging was smaller than that on the initial MIBI imaging in 2 patients with successful emergency PTCR/PTCA. But in the other 2 AMI patients with unsuccessful reperfusion, the defect area did not significantly decrease after PTCR/PTCA. Reperfusion was successful in one of the two patients with OMI. In both the two patients with OMI, the MIBI defect area did not significantly decrease after rescue PTCA. MIBI myocardial scintigraphy is a useful noninvasive method for evaluating the effect of emergency PTCR/PTCA for myocardial salvage in patients with AMI, because MIBI is a kit type agent, and it does not redistribute.
本研究旨在阐明与传统的铊-201心肌闪烁显像（201Tl）相比，锝-99m-六甲基-2-甲氧基异丁基异腈（MIBI）心肌闪烁显像评估经皮冠状动脉腔内血管成形术（PTCR）/经皮冠状动脉腔内血管成形术（PTCA）效果的能力。在急诊PTCR/PTCA前注射99mTc-MIBI（740-888MBq），并在4例急性心肌梗死（AMI）患者PTCR/PTCA后立即进行首次显像。另一方面，在2例陈旧性心肌梗死（OMI）患者中，在抢救性PTCA前和术后1周进行201Tl和MIBI心肌显像。2例急诊PTCR/PTCA成功的患者，随访MIBI显像的缺损面积小于首次MIBI显像。但在另外2例再灌注未成功的AMI患者中，PTCR/PTCA后缺损面积未显著减小。2例OMI患者中有1例再灌注成功。在这2例OMI患者中，抢救性PTCA后MIBI缺损面积均未显著减小。MIBI心肌闪烁显像是评估急诊PTCR/PTCA对AMI患者心肌挽救效果的一种有用的非侵入性方法，因为MIBI是一种试剂盒型药物，且不会再分布。
