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Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXRα.熊去氧胆酸与回肠胆汁酸结合蛋白的异常结合：在 FXRα激活中的作用。
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本文引用的文献

1
Intermittent external biliary drainage for relief of pruritus in certain chronic disorders of the liver.
Surgery. 1947 Jan;21(1):43-5.
2
Intestinal absorption of the bile acid analogue 75Se-homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration.胆汁酸类似物75硒-高胆酸-牛磺酸的肠道吸收在原发性胆汁性肝硬化中增加，而在熊去氧胆酸给药期间恢复正常。
Gut. 2003 Sep;52(9):1371-5. doi: 10.1136/gut.52.9.1371.
3
Structural basis for bile acid binding and activation of the nuclear receptor FXR.胆汁酸结合及核受体FXR激活的结构基础
Mol Cell. 2003 Apr;11(4):1093-100. doi: 10.1016/s1097-2765(03)00112-6.
4
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.核胆汁酸受体FXR的化学、遗传及结构分析
Mol Cell. 2003 Apr;11(4):1079-92. doi: 10.1016/s1097-2765(03)00104-7.
5
Inhibition of both the apical sodium-dependent bile acid transporter and HMG-CoA reductase markedly enhances the clearance of LDL apoB.抑制顶端钠依赖性胆汁酸转运蛋白和HMG-CoA还原酶均能显著增强低密度脂蛋白载脂蛋白B的清除率。
J Lipid Res. 2003 May;44(5):943-52. doi: 10.1194/jlr.M200482-JLR200. Epub 2003 Feb 1.
6
The enzymes, regulation, and genetics of bile acid synthesis.胆汁酸合成的酶、调节与遗传学
Annu Rev Biochem. 2003;72:137-74. doi: 10.1146/annurev.biochem.72.121801.161712. Epub 2003 Jan 16.
7
Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter.肝脏受体同源物-1介导顶端钠依赖性胆汁酸转运体的物种和细胞系特异性胆汁酸依赖性负反馈调节。
J Biol Chem. 2003 May 30;278(22):19909-16. doi: 10.1074/jbc.M207903200. Epub 2002 Nov 26.
8
Bile acid regulation of gene expression: roles of nuclear hormone receptors.胆汁酸对基因表达的调控：核激素受体的作用
Endocr Rev. 2002 Aug;23(4):443-63. doi: 10.1210/er.2000-0035.
9
Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited.熊去氧胆酸在胆汁淤积性肝病中的作用机制及治疗应用再探讨
Hepatology. 2002 Sep;36(3):525-31. doi: 10.1053/jhep.2002.36088.
10
Partial external biliary diversion for intractable pruritus and xanthomas in Alagille syndrome.阿拉吉列综合征中难治性瘙痒和黄瘤的部分外胆道转流术
Hepatology. 2002 Jun;35(6):1501-6. doi: 10.1053/jhep.2002.33332.

Inappropriate ileal conservation of bile acids in cholestatic liver disease: homeostasis gone awry.

作者信息

Hofmann A F

机构信息

Division of Gastroenterology, Department of Medicine, University of California, San Diego 92093-0813, USA.

出版信息

Gut. 2003 Sep;52(9):1239-41. doi: 10.1136/gut.52.9.1239.

DOI:10.1136/gut.52.9.1239
PMID:12912852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1773777/
Abstract
摘要