Cao S L
Cancer Hospital, Shanghai Medical University.
Zhonghua Zhong Liu Za Zhi. 1992 Sep;14(5):327-30.
Tumor growth and cell cycle of human nasopharyngeal carcinoma xenograft in nude mice (NPC-837) after irradiation were studied. After cobalt-60 irradiation of 5.0Gy, 7.5Gy, 10Gy, 15Gy and 20Gy, the tumor volume was reduced to 80, 70, 50, 35 and 10 percent of the control, respectively. However, the tumors began to grow again. The time (in days) the tumors took to reach the volume of the control was radiation dose-dependent. With 20 Gy irradiation the tumor volume was kept at 10% of the control level for as long as 20 days before regrowth occurred, but it never reached the control level up to 108 days of observation. A mean G2 cell block rate of 1.21% after irradiation was observed and a G2 cell block was marked after 7.5Gy irradiation. The results indicate that NPC-837 is a very radiosensitive and valuable model for the radiobiological research of solid tumors.
研究了裸鼠人鼻咽癌移植瘤（NPC - 837）照射后的肿瘤生长及细胞周期。经5.0Gy、7.5Gy、10Gy、15Gy和20Gy的钴 - 60照射后，肿瘤体积分别降至对照组的80%、70%、50%、35%和10%。然而，肿瘤又开始生长。肿瘤达到对照组体积所需的时间（天数）与辐射剂量相关。经20Gy照射后，肿瘤体积在再生长前长达20天保持在对照组水平的10%，但在长达108天的观察期内从未达到对照组水平。照射后观察到平均G2期细胞阻滞率为1.21%，7.5Gy照射后出现明显的G2期细胞阻滞。结果表明，NPC - 837是实体瘤放射生物学研究中一个非常敏感且有价值的模型。
