多羟基化甾体及软珊瑚查氏肾形珊瑚的其他成分。

Polyhydroxylated steroids and other constituents of the soft coral Nephthea chabroli.

作者信息

Zhang Weihan, Liu Wing Keung, Che Chun-Tao

机构信息

Hutchison Medipharma Ltd., Shanghai, China.

出版信息

Chem Pharm Bull (Tokyo). 2003 Aug;51(8):1009-11. doi: 10.1248/cpb.51.1009.

DOI:10.1248/cpb.51.1009

PMID:12913248

Abstract

Polyhydroxylated steroids and other metabolites were isolated from the soft coral Nephthea chabroli collected in South China Sea. The structures of two new compounds were determined to be 24-methylcholesta-9(11), 24(28)-diene-3beta,12alpha,19-triol and 4alpha-methyl-3beta,14beta-dihydroxy-5alpha-ergost-24(28)-en-23-one on the basis of spectroscopic analysis. Cytotoxic activities of the polyhydroxylated sterols were evaluated on prostate carcinoma LNCaP cell line.

摘要

从中国南海采集的软珊瑚查氏肾形珊瑚中分离出多羟基化甾体及其他代谢产物。基于光谱分析确定了两种新化合物的结构，分别为24-甲基胆甾-9(11),24(28)-二烯-3β,12α,19-三醇和4α-甲基-3β,14β-二羟基-5α-麦角甾-24(28)-烯-23-酮。对多羟基化甾醇的细胞毒性活性在前列腺癌LNCaP细胞系上进行了评估。