南海海绵 Plakortis sp. 中四种新的多羟基甾醇

Four new polyhydroxylated steroids from the South Sea sponge Plakortis sp.

机构信息

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Laboratory of Marine Drugs and Biological Products, National Laboratory of Marine Science and Technology, Qingdao 266235, China.

National Museum of Natural History, PO Box 9517, 2300 RA Leiden, the Netherlands.

出版信息

Chin J Nat Med. 2020 Nov;18(11):844-849. doi: 10.1016/S1875-5364(20)60026-7.

DOI:10.1016/S1875-5364(20)60026-7

PMID:33308606

Abstract

Four new polyhydroxylated steroids plaksterols A-D (1-4), together with two known related steroids ergost-7,9(11),22-trien-3β,5α,6α-triol (5) and ergosta-6β-methoxy-7,22-diene-3β,5α-diol (6), were isolated from methanol extract of the South China Sea marine sponge Plakortis sp. Their structures were identified by spectroscopic analysis, including NMR, MS, and IR. The cytotoxicity of the polyhydroxylated steroids were evaluated, and compound 6 showed moderate inhibitory activities against K562, HL-60 and BEL-7402 cells.

摘要

从南海海绵 Plakortis sp. 的甲醇提取物中分离得到了四个新的多羟基甾醇 plaksterols A-D（1-4），以及两个已知的相关甾醇 ergost-7,9(11),22-trien-3β,5α,6α-triol（5）和 ergosta-6β-methoxy-7,22-diene-3β,5α-diol（6）。通过光谱分析，包括 NMR、MS 和 IR，确定了它们的结构。对多羟基甾醇的细胞毒性进行了评价，化合物 6 对 K562、HL-60 和 BEL-7402 细胞表现出中等抑制活性。