Cheng Shi-Yie, Huang Ya-Chiang, Wen Zhi-Hong, Hsu Chi-Hsin, Wang Shang-Kwei, Dai Chang-Feng, Duh Chang-Yih
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Steroids. 2009 Jun;74(6):543-7. doi: 10.1016/j.steroids.2009.02.004. Epub 2009 Feb 24.
Chemical investigation of the Formosan soft coral Nephthea chabroli resulted in the isolation of four new 19-oxygenated steroids, nebrosteroids I-L (1-4), together with a new 4alpha-methylated steroid, nebrosteroid M (5). The molecular structures of these isolated metabolites were elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related metabolites. Compounds 1-5 were evaluated for anti-inflammatory activity using RAW 264.7 macrophages.
对台湾软珊瑚扁形软珊瑚进行化学研究，从中分离出四种新的19-氧化甾体化合物，即扁形甾体I-L（1-4），以及一种新的4α-甲基化甾体化合物，扁形甾体M（5）。通过广泛的光谱分析，并将数据与相关代谢物的数据进行比较，阐明了这些分离出的代谢物的分子结构。使用RAW 264.7巨噬细胞对化合物1-5进行抗炎活性评估。
