Kullenberg R, Falch J A
Demetech AB, Solna, Sweden.
Osteoporos Int. 2003 Oct;14(10):823-7. doi: 10.1007/s00198-003-1442-z. Epub 2003 Aug 12.
Using manufacturers reference data the prevalence of osteoporosis using a T-score threshold of -2.5 for heel measurements by DXL technology was compared to dual-energy X-ray absorptiometry (DXA) measurements at the femoral neck, spine and forearm. The prevalence of osteoporosis for women aged 50 years or older was 28% for DXL measurements of the heel bone and 30, 22 and 32% for DXA measurements of the lumbar spine, femoral neck and forearm respectively. Bone mineral density (BMD) was also measured by DXL in the heel bone and by DXA in spine and femoral neck in 251 women (mean age 62 +/- 14.5 years) when attending an osteoporosis clinic. The sensitivity and specificity for osteoporosis and osteopenia for the DXL measurements were calculated assuming a low T-score at the spine or femoral neck as the criterion for a correct diagnosis. The sensitivity was found to be 80% for osteoporosis and 82% for osteopenia and the specificity was 82% for osteoporosis and 89% for osteopenia. We conclude that DXL measurement at the heel bone, using a T-score threshold of -2.5 for classification of osteoporosis, is in concordance with the World Health Organization (WHO) definition of osteoporosis.
利用制造商的参考数据，将采用双能X线吸收法（DXA）技术测量足跟时T值阈值为-2.5诊断骨质疏松症的患病率，与在股骨颈、脊柱和前臂进行双能X线吸收法（DXA）测量的结果进行比较。50岁及以上女性中，足跟骨DXL测量骨质疏松症的患病率为28%，而腰椎、股骨颈和前臂DXA测量的患病率分别为30%、22%和32%。在251名（平均年龄62±14.5岁）前往骨质疏松症门诊就诊的女性中，还采用DXL测量足跟骨骨密度（BMD），采用DXA测量脊柱和股骨颈骨密度。以脊柱或股骨颈低T值作为正确诊断标准，计算DXL测量骨质疏松症和骨量减少的敏感性和特异性。结果发现，骨质疏松症的敏感性为80%，骨量减少的敏感性为82%；骨质疏松症的特异性为82%，骨量减少的特异性为89%。我们得出结论，足跟骨DXL测量采用T值阈值-2.5诊断骨质疏松症，与世界卫生组织（WHO）对骨质疏松症的定义一致。
