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A novel implant surface modification mode of Fe3O4-containing TiO2 nanorods with sinusoidal electromagnetic field for osteoblastogenesis and angiogenesis.

作者信息

Ren Ranyue, Guo Jiachao, Song Hao, Wei Yong, Luo Chao, Zhang Yayun, Chen Liangxi, Gao Biao, Fu Jijiang, Xiong Wei

机构信息

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

出版信息

Mater Today Bio. 2023 Feb 22;19:100590. doi: 10.1016/j.mtbio.2023.100590. eCollection 2023 Apr.

DOI:10.1016/j.mtbio.2023.100590
PMID:36910272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9996442/
Abstract

Implants made of Ti and its alloys are widely utilized in orthopaedic surgeries. However, insufficient osseointegration of the implants often causes complications such as aseptic loosening. Our previous research discovered that disordered titanium dioxide nanorods (TNrs) had satisfactory antibacterial properties and biocompatibility, but TNrs harmed angiogenic differentiation, which might retarded the osseointegration process of the implants. Magnetic nanomaterials have a certain potential in promoting osseointegration, electromagnetic fields within a specific frequency and intensity range can facilitate angiogenic and osteogenic differentiation. Therefore, this study used FeO to endow magnetism to TNrs and explored the regulation effects of Ti, TNrs, and FeO-TNrs under 1 ​mT 15 ​Hz sinusoidal electromagnetic field (SEMF) on osteoblastogenesis, osseointegration, angiogenesis, and its mechanism. We discovered that after the addition of SEMF treatment to VR-EPCs cultured on FeO-TNrs, the calcineurin/NFAT signaling pathway was activated, which then reversed the inhibitory effect of FeO-TNrs on angiogenesis. Besides, FeO-TNrs with SEMF enhanced osteogenic differentiation and osseointegration. Therefore, the implant modification mode of FeO-TNrs with the addition of SEMF could more comprehensively promote osseointegration and provided a new idea for the modification of implants.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/da1e4b759ca6/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/090e3d552c23/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/e94f58734cff/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/69a8451f592a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/297c79f41221/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/464aa77b5f5a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/5cfb67f314d3/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/16dfff1a0061/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/da1e4b759ca6/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/090e3d552c23/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/e94f58734cff/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/69a8451f592a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/297c79f41221/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/464aa77b5f5a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/5cfb67f314d3/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/16dfff1a0061/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4f/9996442/da1e4b759ca6/gr7.jpg

相似文献

[1]
A novel implant surface modification mode of Fe3O4-containing TiO2 nanorods with sinusoidal electromagnetic field for osteoblastogenesis and angiogenesis.

Mater Today Bio. 2023-2-22

[2]
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[3]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Advanced surface modification techniques for titanium implants: a review of osteogenic and antibacterial strategies.

Front Bioeng Biotechnol. 2025-3-19

[2]
Fabrication of Magnetic Poly(L-lactide) (PLLA)/FeO Composite Electrospun Fibers.

Materials (Basel). 2024-8-1

[3]
Black phosphorus quantum dot-modified ADSCs as a novel therapeutic for periodontitis bone loss coupling of osteogenesis and osteoimmunomodulation.

Mater Today Bio. 2024-6-10

本文引用的文献

[1]
Stimulation of Metabolic Activity and Cell Differentiation in Osteoblastic and Human Mesenchymal Stem Cells by a Nanohydroxyapatite Paste Bone Graft Substitute.

Materials (Basel). 2022-2-19

[2]
The role of Ca /Calcineurin/NFAT signalling pathway in osteoblastogenesis.

Cell Prolif. 2021-11

[3]
Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis.

Bioact Mater. 2020-10-7

[4]
PERK controls bone homeostasis through the regulation of osteoclast differentiation and function.

Cell Death Dis. 2020-10-13

[5]
Novel Bionic Topography with MiR-21 Coating for Improving Bone-Implant Integration through Regulating Cell Adhesion and Angiogenesis.

Nano Lett. 2020-10-14

[6]
Cholinergic control of bone development and beyond.

Int Immunopharmacol. 2020-6

[7]
PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission.

Aging (Albany NY). 2020-2-25

[8]
PKM2 regulates angiogenesis of VR-EPCs through modulating glycolysis, mitochondrial fission, and fusion.

J Cell Physiol. 2020-9

[9]
Ambient and supplemental magnetic fields promote myogenesis a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism.

FASEB J. 2019-9-13

[10]
Long-lasting bactericidal activity through selective physical puncture and controlled ions release of polydopamine and silver nanoparticles-loaded TiO nanorods in vitro and in vivo.

Int J Nanomedicine. 2019-4-24

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