Ioannou C V, Stergiopulos N, Katsamouris A N, Startchik I, Kalangos A, Licker M J, Westerhof N, Morel D R
Division of Vascular Surgery, University Hospital, University of Crete Medical School, 711 10 Heraklion, Greece.
Eur J Vasc Endovasc Surg. 2003 Aug;26(2):195-204. doi: 10.1053/ejvs.2002.1917.
to investigate the affect of reduced aortic compliance on cardiovascular hemodynamics.
fourteen Yucatan miniature swine were divided into two equal groups, a Sham Operated Group and a Banding Group. A Teflon prosthesis was wrapped around the aortic arc in order to limit proximal aortic compliance (Banding Group). Data were recorded operatively (after implantation of a pressure sensor and a flow probe in the ascending aorta), after banding (only in the Banding Group) and at 2 days postoperatively.
after banding, compliance decreased by 52 +/- 13% ((-)X +/- SEM) (p < 0.01) while systolic and pulse pressure increased by 37 +/- 8% (p < 0.05) and 87 +/- 31% (p < 0.01), respectively. Diastolic pressure, mean blood pressure, cardiac output and systemic vascular resistance did not change significantly. Aortic characteristic impedance increased nearly 2.5 times. Amplitudes of forward and reflected pressure waves (derived from the aortic pressure wave) increased by 96 +/- 41% and 174 +/- 46%, respectively (p < 0.05), while the time delay between the two decreased by 36 +/- 7% (p < 0.05).
about half of the total arterial compliance is located in the proximal thoracic aorta. Arterial reconstruction of the proximal aorta with a non-compliant graft results in a significant decrease in systemic arterial compliance, which in turn increases systolic and pulse pressure. The development of more compliant prosthesis, which matches the host artery compliance, is expected to reduce the hemodynamic changes induced after their implantation.
研究主动脉顺应性降低对心血管血流动力学的影响。
将14只尤卡坦小型猪分为两组，每组数量相等，即假手术组和结扎组。用聚四氟乙烯假体包裹主动脉弓以限制近端主动脉顺应性（结扎组）。在手术过程中（在升主动脉植入压力传感器和流量探头后）、结扎后（仅在结扎组）以及术后2天记录数据。
结扎后，顺应性降低了52±13%（（-）X±SEM）（p<0.01），而收缩压和脉压分别升高了37±8%（p<0.05）和87±31%（p<0.01）。舒张压、平均血压、心输出量和全身血管阻力无显著变化。主动脉特征阻抗增加了近2.5倍。正向和反射压力波（由主动脉压力波得出）的振幅分别增加了96±41%和174±46%（p<0.05），而两者之间的时间延迟减少了36±7%（p<0.）。
总动脉顺应性约一半位于胸段主动脉近端。用顺应性差的移植物对主动脉近端进行动脉重建会导致全身动脉顺应性显著降低，进而增加收缩压和脉压。开发与宿主动脉顺应性相匹配的更顺应性的假体有望减少植入后引起的血流动力学变化。
