Malosse D, Perron H, Sasco A, Seigneurin J M
Laboratoire de Virologie, Faculté de Médecine, CHRU, Grenoble, France.
Neuroepidemiology. 1992;11(4-6):304-12. doi: 10.1159/000110946.
Multiple sclerosis (MS) epidemiology suggests that different factors are involved in the clinical expression of the disease. Alimentary cofactors have already been considered, but mainly theoretically. We have studied the relationship between MS prevalence and dairy product consumption in 27 countries and 29 populations all over the world, with Spearman's correlation test. A good correlation between liquid cow milk and MS prevalence (rho = 0.836) was found; this correlation was highly significant (p < 0.001). A low but still significant correlation was obtained with cream or butter consumption (rho = 0.619 and rho = 0.504, respectively). No correlation was found for cheese. These results suggest that liquid cow milk could contain factor(s) - no longer present in the processed milk - influencing the clinical appearance of MS. The possible role of some dairy by-products is discussed in the light of a multifactorial etiology of MS.
多发性硬化症（MS）的流行病学研究表明，多种不同因素与该疾病的临床表现有关。饮食辅助因素已被考虑在内，但主要是从理论层面。我们运用斯皮尔曼相关性检验，研究了全球27个国家和29个人口群体中MS患病率与乳制品消费之间的关系。结果发现，液态牛奶与MS患病率之间存在良好的相关性（rho = 0.836）；这种相关性高度显著（p < 0.001）。食用奶油或黄油也呈现出较低但仍显著的相关性（rho分别为0.619和0.504）。而奶酪则未发现相关性。这些结果表明，液态牛奶可能含有某些因素——这些因素在加工牛奶中已不复存在——影响着MS的临床表现。鉴于MS的多因素病因，我们讨论了一些乳制品副产品可能发挥的作用。
