Chabot Isabelle, Moisan Jocelyne, Grégoire Jean-Pierre, Milot Alain
Department of Health Economics & Outcomes Research, Merck Frosst Canada Ltd., Kirkland, Québec, Canada.
Ann Pharmacother. 2003 Sep;37(9):1186-93. doi: 10.1345/aph.1C267.
Pharmaceutical care programs have been shown to improve outcomes in hypertension. However, most programs required direct access to patient medical chart and patient consultation sessions by appointment.
To follow the current practice of community pharmacy, exploring the effect of an intervention program on blood pressure (BP) and factors affecting BP.
Treated hypertensive patients were enrolled in a 9-month controlled study involving 9 community pharmacies. The PRECEDE-PROCEED model was used as conceptual framework to identify factors affecting BP, to incorporate those factors in an intervention program, and to evaluate the impact of the program. A computerized decision-aid tool was used by pharmacists from 4 pharmacies to provide pharmaceutical care to subjects (n = 41); pharmacists from the 5 other pharmacies performed usual care (n = 59). As there was a statistically significant interaction due to family income in describing the impact of pharmacists' intervention on BP, population was stratified by family income in the analyses.
Compared with the control group, the pharmacy program resulted in significant systolic BP reduction (-7.8 vs. 0.5 mm Hg; p = 0.01) and an increase in the proportion of controlled patients only for those with high incomes. In the high-income group, the program also had a positive impact on physical activity, self-reported adherence, health concerns, and information transmitted. The low-income group did not appear to benefit from the program.
Pharmacist intervention can modify factors affecting adherence, improve adherence, and reduce BP levels in patients treated with antihypertensive agents. Impact of pharmacist intervention on BP differed according to patient income status.
药学服务项目已被证明可改善高血压的治疗效果。然而,大多数项目需要直接查阅患者病历并通过预约安排患者咨询环节。
遵循社区药房的现行做法,探讨一项干预项目对血压(BP)及影响血压的因素的作用。
将接受治疗的高血压患者纳入一项为期9个月的对照研究,该研究涉及9家社区药房。采用PRECEDE-PROCEED模型作为概念框架,以识别影响血压的因素,将这些因素纳入一项干预项目,并评估该项目的影响。4家药房的药剂师使用计算机化决策辅助工具为受试者(n = 41)提供药学服务;其他5家药房的药剂师提供常规护理(n = 59)。由于在描述药剂师干预对血压的影响时家庭收入存在统计学上的显著交互作用,因此在分析中按家庭收入对人群进行分层。
与对照组相比,药房项目使收缩压显著降低(-7.8 vs. 0.5 mmHg;p = 0.01),且仅使高收入患者的血压控制率有所提高。在高收入组中,该项目对身体活动、自我报告的依从性、健康关注度和信息传递也有积极影响。低收入组似乎未从该项目中受益。
药剂师干预可改变影响依从性的因素,提高依从性,并降低接受抗高血压药物治疗患者的血压水平。药剂师干预对血压的影响因患者收入状况而异。