Rinfret Stéphane, Lussier Marie-Thérèse, Peirce Anthony, Duhamel Fabie, Cossette Sylvie, Lalonde Lyne, Tremblay Chantal, Guertin Marie-Claude, LeLorier Jacques, Turgeon Jacques, Hamet Pavel
Centre de recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Circ Cardiovasc Qual Outcomes. 2009 May;2(3):170-7. doi: 10.1161/CIRCOUTCOMES.108.823765. Epub 2009 May 5.
Hypertension is a leading mortality risk factor yet inadequately controlled in most affected subjects. Effective programs to address this problem are lacking. We hypothesized that an information technology-supported management program could help improve blood pressure (BP) control.
This randomized controlled trial included 223 primary care hypertensive subjects with mean 24-hour BP >130/80 and daytime BP >135/85 mm Hg measured with ambulatory monitoring (ABPM). Intervention subjects received a BP monitor and access to an information technology-supported adherence and BP monitoring system providing nurses, pharmacists, and physicians with monthly reports. Control subjects received usual care. The mean (+/-SD) follow-up was 348 (+/-78) and 349 (+/-84) days in the intervention and control group, respectively. The primary end point of the change in the mean 24-hour ambulatory BP was consistently greater in intervention subjects for both systolic (-11.9 versus -7.1 mm Hg; P<0.001) and diastolic BP (-6.6 versus -4.5 mm Hg; P=0.007). The proportion of subjects that achieved Canadian Guideline target BP (46.0% versus 28.6%) was also greater in the intervention group (P=0.006). We observed similar BP declines for ABPM and self-recorded home BP suggesting the latter could be an alternative for confirming BP control. The intervention was associated with more physician-driven antihypertensive dose adjustments or changes in agents (P=0.03), more antihypertensive classes at study end (P=0.007), and a trend toward improved adherence measured by prescription refills (P=0.07).
This multidisciplinary information technology-supported program that provided feedback to patients and healthcare providers significantly improved blood pressure levels in a primary care setting.
高血压是主要的死亡风险因素,但在大多数患者中控制不佳。目前缺乏有效的解决该问题的方案。我们假设信息技术支持的管理方案有助于改善血压(BP)控制。
这项随机对照试验纳入了223名初级保健高血压患者,通过动态血压监测(ABPM)测得平均24小时血压>130/80 mmHg且日间血压>135/85 mmHg。干预组患者获得一台血压监测仪,并可使用信息技术支持的依从性和血压监测系统,该系统每月为护士、药剂师和医生提供报告。对照组患者接受常规护理。干预组和对照组的平均(±标准差)随访时间分别为348(±78)天和349(±84)天。干预组患者24小时动态血压均值变化的主要终点在收缩压(-11.9 vs -7.1 mmHg;P<0.001)和舒张压(-6.6 vs -4.5 mmHg;P=0.007)方面均持续高于对照组。干预组达到加拿大指南目标血压的患者比例(46.0% vs 28.6%)也更高(P=0.006)。我们观察到动态血压监测和家庭自测血压的血压下降情况相似,这表明后者可作为确认血压控制的替代方法。干预与更多由医生推动的降压药物剂量调整或药物更换相关(P=0.03),研究结束时使用的降压药物种类更多(P=0.007),并且通过处方续配衡量的依从性有改善趋势(P=0.07)。
这个为患者和医疗服务提供者提供反馈的多学科信息技术支持方案在初级保健环境中显著改善了血压水平。