Valtysdottir S Th, Wide L, Hallgren R
Uppsala University Hospital, Uppsala, Sweden.
Ann Rheum Dis. 2003 Sep;62(9):875-9. doi: 10.1136/ard.62.9.875.
To evaluate the possible effect of androgen status on sexuality and mental wellbeing in patients with primary Sjögren's syndrome (pSS).
Serum levels of dehydroepiandrosterone sulphate (DHEA-S), testosterone (T), androstenedione, sex hormone binding globulin (SHBG), and the SHBG/T ratio were measured in 21 women with pSS. Sexual life was assessed by a Swedish version of the McCoy scale, which covers sexual experience and responsiveness during the past 30 days. A standardised questionnaire, the Psychological General Well-Being Index (PGWB), was used to examine quality of life and psychological symptoms in patients with pSS.
Positive correlations were found between DHEA-S serum levels and the total McCoy score (r(s)=0.62; p<0.01), as well as the subscales of this score reflecting arousal (0.59; p<0.05), desire (r(s)=0.52; p<0.05), and satisfaction (r(s)=0.66; p<0.01). Serum DHEA-S concentrations were also related to the total PGWB score (r(s)=0.60; p<0.01) and subscales of this score: depression (r(s)=0.62; p<0.01), wellbeing (r(s)=0.64; p<0.01), general health (r(s)=0.67; p<0.01), and self control (r(s)=0.67; p<0.01). Total McCoy and PGWB scores and their subscales were not related to the serum levels of testosterone and androstenedione or the T/SHBG ratio.
Circulating levels of the weak androgen DHEA-S are positively related to the quality of sexual life and mental wellbeing in women with pSS.
评估雄激素状态对原发性干燥综合征（pSS）患者性功能和心理健康的可能影响。
检测21例pSS女性患者血清硫酸脱氢表雄酮（DHEA-S）、睾酮（T）、雄烯二酮、性激素结合球蛋白（SHBG）水平及SHBG/T比值。采用瑞典版麦考伊量表评估性生活情况，该量表涵盖过去30天的性体验和性反应。使用标准化问卷“心理总体幸福感指数（PGWB）”来检查pSS患者的生活质量和心理症状。
DHEA-S血清水平与麦考伊总分（r(s)=0.62；p<0.01）以及该评分中反映性唤起（0.59；p<0.05）、性欲（r(s)=0.52；p<0.05）和满意度（r(s)=0.66；p<0.01）的子量表呈正相关。血清DHEA-S浓度还与PGWB总分（r(s)=0.60；p<0.01）及其子量表相关：抑郁（r(s)=0.62；p<0.01）、幸福感（r(s)=0.64；p<0.01）、总体健康状况（r(s)=0.67；p<0.01）和自我控制能力（r(s)=0.67；p<0.01）。麦考伊总分和PGWB总分及其子量表与睾酮和雄烯二酮的血清水平或T/SHBG比值无关。
在pSS女性患者中，弱雄激素DHEA-S的循环水平与性生活质量和心理健康呈正相关。
