Yano A, Yasukawa M, Yanagisawa K, Hasegawa H, Hato T, Minamoto Y, Kohno H, Kondo T, Fujita S, Kobayashi Y
First Department of Internal Medicine, Ehime University School of Medicine, Japan.
Acta Haematol. 1992;88(4):207-12. doi: 10.1159/000204689.
The mechanism of eosinophilia in a patient with adult T cell leukemia (ATL) was investigated. A 61-year-old woman with ATL presented marked eosinophilia. No parasite infections or allergic diseases were found in this patient. The number of eosinophils fluctuated in parallel with that of ATL cells during her clinical course. The patient's serum and the culture supernatant of ATL cells showed eosinophil colony-stimulating activity. Northern blot analysis of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5), which are known eosinophil CSFs, showed that only GM-CSF but not IL-3 or IL-5 was expressed in freshly separated and cultured ATL cells. Since neutrophil and monocyte numbers did not increase, it is suggested that GM-CSF and unknown cytokines other than IL-3 and IL-5 produced by ATL cells synergistically stimulated eosinophil precursors in the present case.
对一名成人T细胞白血病（ATL）患者嗜酸性粒细胞增多的机制进行了研究。一名61岁的ATL女性患者出现明显的嗜酸性粒细胞增多。该患者未发现寄生虫感染或过敏性疾病。在其临床病程中，嗜酸性粒细胞数量与ATL细胞数量平行波动。患者血清及ATL细胞培养上清液显示出嗜酸性粒细胞集落刺激活性。对已知的嗜酸性粒细胞集落刺激因子粒细胞-巨噬细胞集落刺激因子（GM-CSF）、白细胞介素-3（IL-3）和白细胞介素-5（IL-5）进行Northern印迹分析，结果显示，在新鲜分离和培养的ATL细胞中，仅表达GM-CSF，而不表达IL-3或IL-5。由于中性粒细胞和单核细胞数量未增加，提示在本病例中，ATL细胞产生的GM-CSF以及IL-3和IL-5以外的未知细胞因子协同刺激了嗜酸性粒细胞前体。
