Said R, Tarawneh M
Department of Medicine, School of Medicine, Jordan University, Amman.
Am J Nephrol. 1992;12(6):466-70. doi: 10.1159/000168500.
A 14-year-old boy presented with fever, anemia, hepatosplenomegaly, generalized lymphadenopathy and nephrotic syndrome. Lymph node biopsy showed angiofollicular lymph node hyperplasia (generalized Castleman's disease) of the plasma cell type. Kidney biopsy showed membranoproliferative glomerulonephritis type 1. Complete remission was achieved with corticosteroid treatment and repeat kidney biopsy 22 months later showed complete resolution of the renal pathology. The association between membranoproliferative glomerulonephritis and multicentric angiofollicular lymph node hyperplasia, plasma cell type, has not previously been reported.
一名14岁男孩出现发热、贫血、肝脾肿大、全身淋巴结肿大及肾病综合征。淋巴结活检显示为浆细胞型血管滤泡性淋巴结增生（全身性Castleman病）。肾脏活检显示为1型膜增生性肾小球肾炎。经皮质类固醇治疗后实现完全缓解，22个月后重复肾脏活检显示肾脏病理完全消退。此前尚未报道过1型膜增生性肾小球肾炎与多中心浆细胞型血管滤泡性淋巴结增生之间的关联。
