Lui S L, Chan K W, Li F K, Cheng I K, Chan T M
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam.
Nephron. 1998;78(3):323-7. doi: 10.1159/000044943.
Renal complications of Castleman's disease (angiofollicular lymph node hyperplasia) are uncommon. The reported cases are very heterogeneous and their renal pathology ranged from minimal change disease, mesangial proliferative glomerulonephritis, to amyloidosis. We have previously reported two cases of Castleman's disease with renal complications. We now present two more such cases. In contrast to other reports, all our cases are of the plasma cell type and their renal pathology showed remarkable similarities, namely mesangial proliferation, interstitial plasma cell infiltration and negative immunofluorescence. The level of serum interleukin-6 (IL-6) in both patients was elevated at presentation and came down with immunosuppressive therapy.
卡斯特曼病（血管滤泡性淋巴结增生）的肾脏并发症并不常见。报道的病例非常多样化，其肾脏病理表现从微小病变肾病、系膜增生性肾小球肾炎到淀粉样变性不等。我们之前曾报道过两例伴有肾脏并发症的卡斯特曼病病例。现在我们再介绍另外两例此类病例。与其他报道不同的是，我们所有的病例均为浆细胞型，其肾脏病理表现出显著的相似性，即系膜增生、间质浆细胞浸润以及免疫荧光阴性。两名患者就诊时血清白细胞介素-6（IL-6）水平均升高，免疫抑制治疗后下降。
