Lernfelt B, Samuelsson O, Skoog I, Landahl S
Department of Geriatric Medicine, University of Gothenburg, Vasa Hospital, 411 33 Gothenburg, Sweden.
Eur J Clin Pharmacol. 2003 Nov;59(8-9):637-44. doi: 10.1007/s00228-003-0647-6. Epub 2003 Aug 16.
To investigate changes in drug treatment among elderly men and women over a 29-year period between 1971 and 2000.
Drug consumption was investigated in five representative population samples of 70-year-olds born in 1901-1902 (n=973), 1906-1907 (n=1036), 1911-1912 (n=619), 1922 (n=449) and 1930 (n=506) and in three representative samples of 79- to 80-year-olds born in 1901-1902 (n=537), 1906-1907 (n=538) and 1915 (n=212).
The proportion of 70-year-olds who used drugs increased from 60% to 79% in men and from 76% to 88% in women from 1972 to 2000. Among 80-year-olds, 21% of the men and 11% of the women were without drug treatment in 1980, compared with 7% in 1995. The average number of drugs among 70-year-olds on treatment increased during the observation period from 2.8 to 3.5 in men and from 2.8 to 4.0 in women. At age 79-80 years, the mean number of drugs was 3.3 in men and 4.0 in women in 1980 and 4.0 in men and 4.7 in women in 1995. The most common drugs were cardiovascular drugs, analgesics and drugs for diseases in the central nervous system. The most pronounced changes in the consumption of specific drugs were found for anti-ulcerative drugs (increased), digitalis (decreased), diuretics (decreased in women), anti-thrombotic drugs (increased), calcium/vitamin D (increased), insulin (increased in men aged 70 years), analgesics (increased), levaxin (increased in women), anti-depressants (increased in women aged 70 years) and oestrogen in women (increased). The treatment patterns for cardiovascular diseases changed during the observation period and the use of calcium antagonists, angiotensin converting enzyme inhibitors, beta-blockers and lipid-lowering drugs increased.
The proportion of the population with drug treatment at ages 70 years and 79-80 years increased as did the average number of drugs among treated subjects between 1971 and 2000. Important differences in the treatment patterns for different diseases were observed.
调查1971年至2000年期间29年间老年男性和女性药物治疗情况的变化。
对出生于1901 - 1902年（n = 973）、1906 - 1907年（n = 1036）、1911 - 1912年（n = 619）、1922年（n = 449）和1930年（n = 506）的五个具有代表性的70岁人群样本以及出生于1901 - 1902年（n = 537）、1906 - 1907年（n = 538）和1915年（n = 212）的三个具有代表性的79至80岁人群样本的药物消费情况进行了调查。
1972年至2000年期间，70岁男性使用药物的比例从60%增至79%，女性从76%增至88%。在80岁人群中，1980年21%的男性和11%的女性未接受药物治疗，而1995年这一比例为7%。在观察期内，接受治疗的70岁人群平均用药数量男性从2.8增至3.5，女性从2.8增至4.0。在79 - 80岁年龄段，1980年男性平均用药数量为3.3，女性为4.0；1995年男性为4.0，女性为4.7。最常用的药物为心血管药物、镇痛药和中枢神经系统疾病用药。特定药物消费中变化最为显著的有抗溃疡药物（增加）、洋地黄（减少）、利尿剂（女性减少）、抗血栓药物（增加）、钙/维生素D（增加）、胰岛素（70岁男性增加）、镇痛药（增加）、左氧氟沙星（女性增加）、抗抑郁药（70岁女性增加）以及女性雌激素（增加）。观察期内心血管疾病的治疗模式发生了变化，钙拮抗剂、血管紧张素转换酶抑制剂、β受体阻滞剂和降脂药物的使用增加。
1971年至2000年期间，70岁以及79 - 80岁接受药物治疗的人群比例增加，接受治疗者的平均用药数量也增加。不同疾病的治疗模式存在重要差异。
