Vernigora A N, Mikhaĭlova O E, Gengin M T, Ryzhkova Iu A, Mukhina E S
Penza State Pedagogical University, Russia.
Ukr Biokhim Zh (1999). 2002 Nov-Dec;74(6):128-30.
It is discovered that chronic consumption of ethanol induced decrease of carboxypeptidase H activity in striatum by 27%; increase of carboxypeptidase M activity in hippocampus by 67% and decrease in cerebral hemispheres by 34%; phenylmethylsulfonyl fluoride-inhibited carboxypeptidase activity increase in hypothalamus by 141%, in striatum by 60% and in optic and lamina quadrigemina by 34%. The role of basic carboxypeptidases in mechanisms of ethanol influence on the peptidergic systems are discussed.
研究发现，长期摄入乙醇会导致纹状体中羧肽酶H的活性降低27%；海马体中羧肽酶M的活性增加67%，大脑半球中羧肽酶M的活性降低34%；苯甲基磺酰氟抑制的羧肽酶活性在下丘脑增加141%，在纹状体增加60%，在视交叉和四叠体板增加34%。本文讨论了碱性羧肽酶在乙醇对肽能系统影响机制中的作用。
