Kraĭnova T A, Efremova L M, Mukhina I V, Anastasiev V V
ImBio Company, State Enterprise for Production of Bacterial Preparations, Gruzinskaya ul. 44, Nizhni Novgorod, 603950 Russia.
Eksp Klin Farmakol. 2003 May-Jun;66(3):62-5.
The antioxidant and antihypoxant effects of the drug ceruloplasmin were studied on an experimental model of hypobaric hypoxia in rats. Two forms of the drug characterized by low and high enzymatic activity were administered (intramuscularly or intraperitoneally) 20 min or 1 day before hypobaric hypoxia test. The drug effect was independent of the enzymatic activity level. The maximum activity of ceruloplasmin was observed when the drug was administered one day before test. Analyses showed that the drug activated superoxide dismutase, while not changing the catalase activity.
在大鼠低压缺氧实验模型上研究了药物铜蓝蛋白的抗氧化和抗低氧作用。以低酶活性和高酶活性为特征的两种形式的该药物，在低压缺氧试验前20分钟或1天（通过肌肉注射或腹腔注射）给药。药物效果与酶活性水平无关。当在试验前1天给药时，观察到铜蓝蛋白的最大活性。分析表明，该药物激活了超氧化物歧化酶，而过氧化氢酶活性未发生变化。
