Hisdal Jonny, Toska Karin, Walløe Lars
Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway.
Aviat Space Environ Med. 2003 Aug;74(8):874-8.
We have designed a lower body negative pressure (LBNP) chamber and control system that makes it possible to apply LBNP either very rapidly (< 300 ms), or more gradually, according to predefined protocols. The capability of the new, high-performance agile aircraft to reach a high-G onset rate makes it highly desirable to be able to study immediate, rapid, and transient cardiovascular responses to simulated gravitational stress. Our new LBNP chamber has been used to study the main cardiovascular variables during onset and release of mild LBNP (-20 mmHg). We have revealed large transient physiological responses during the onset and release of mild LBNP. This new finding was largely made possible by precise control of the onset and release of LBNP during the experiments. The purpose of this paper is therefore to describe some of the technical solutions which made rapid and controlled changes in LBNP possible, focusing on the importance of precise control of the LBNP chamber.
我们设计了一种下体负压（LBNP）舱及控制系统，该系统能够根据预定义方案，以极快速度（<300毫秒）或更缓慢地施加LBNP。新型高性能敏捷飞机具备高过载起始率，这使得研究对模拟重力应激的即时、快速及短暂心血管反应变得非常必要。我们的新型LBNP舱已用于研究轻度LBNP（-20 mmHg）起始和解除过程中的主要心血管变量。我们发现，在轻度LBNP起始和解除过程中存在较大的短暂生理反应。这一新发现很大程度上得益于实验过程中对LBNP起始和解除的精确控制。因此，本文旨在描述一些使LBNP实现快速且可控变化的技术方案，重点阐述LBNP舱精确控制的重要性。
