Amery A, Birkenhäger W H, Fagard R, Staessen J, Thijs L, de Leeuw P W
Cardiovasc Drugs Ther. 1992 Dec;6(6):565-9. doi: 10.1007/BF00052555.
Recent outcome trials in patients above age 60 with systolo-diastolic hypertension are reviewed. The meta-analysis suggests that antihypertensive drug therapy can decrease cardiovascular and coronary mortality in selected patients. Based on these studies it is suggested that antihypertensive drug therapy is indicated in patients between age 60 and 75 when the diastolic pressure remains above 95 mmHg after repeated measurements. A target for systolic b.p. is not definitely established but a pressure of 150 mmHg may serve as a temporary proposal. Whether uncomplicated isolated systolic hypertension in symptomless patients should be treated is still under investigation.
本文回顾了近期针对60岁以上收缩期-舒张期高血压患者的疗效试验。荟萃分析表明，抗高血压药物治疗可降低特定患者的心血管和冠心病死亡率。基于这些研究，建议在60至75岁的患者中，当多次测量舒张压仍高于95mmHg时，应进行抗高血压药物治疗。收缩压的目标尚未明确确定，但150mmHg的血压可作为临时建议。无症状患者的单纯性收缩期高血压是否应接受治疗仍在研究中。
