Caccappolo-van Vliet Elise, Miozzo Michele, Marder Karen, Stern Yaakov
Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, New York, NY, USA.
Neurocase. 2003 Aug;9(4):297-307. doi: 10.1076/neur.9.4.297.15550.
RB, a patient with probable Alzheimer's disease, makes continuous perseverations of single letters when writing (e.g. fruit-->fruuit), particularly on high frequency letters. An analysis of her errors reveals that her perseverations do not reflect letter substitutions or transpositions, nor do they suggest difficulty with geminates. No continuous perseverations were found in oral production, in graphic and simple motor tasks, and in oral spelling. RB's data do not support an attention deficit as the basis of her continuous perseverations. It is proposed that a deficit at the level of abstract letter representations is the source of RB's perseverations. The implications of this conclusion for accounts of perseveration and of spelling models are discussed.
RB是一名可能患有阿尔茨海默病的患者，她在书写时会不断重复单个字母（例如，fruit写成fruuit），尤其是高频字母。对她的错误进行分析后发现，她的重复并非字母替换或换位，也未表明双辅音字母存在困难。在口语表达、图形和简单运动任务以及口语拼写中均未发现持续的重复现象。RB的数据不支持将注意力缺陷作为其持续重复的基础。研究认为，抽象字母表征层面的缺陷是RB重复现象的根源。本文讨论了这一结论对重复现象解释和拼写模型的影响。
