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[写作、衰老与阿尔茨海默病]

[Writing, aging and Alzheimer's disease].

作者信息

Croisile Bernard

机构信息

Laboratoire de neuropsychologie--fonctions cognitives, langage, mémoire, Hôpital neurologique, Lyon.

出版信息

Psychol Neuropsychiatr Vieil. 2005 Sep;3(3):183-97.

Abstract

Writing is a complex and fragile cognitive function, that appeared very late in the history of mankind, and that also develops quite late in individuals. Aging does not induce changes in the lexical, semantic and syntaxic parameters of the writing description of a complex image. In the same way, spelling is not significantly altered through aging. Spelling errors are rare among seniors: they only concern infrequent words and mostly respect their pronunciation. The most frequent errors are about accents or double letters. Margins get smaller, seniors raise their pens less often and the pressure and width of writing decrease with age. Writing get progressively disorganized during Alzheimer's disease. The content of texts is primarily affected, texts becoming shorter and less coherent. Then, spelling is altered by regularization errors which are an evidence of lexical agraphia. Then, lexical agraphia gets worse and rapidly becomes mixed, combining lexical and phonological features. Finally, dementia worsens along with a massive deterioration of graphic features and spatial organization. Agraphia of Alzheimer's disease comes from a progressive and hierarchized disorganization of the various components of language and writing, due to the brain lesions in several associative areas, i.e. the parietal, temporal, occipital and frontal regions.

摘要

书写是一种复杂且脆弱的认知功能,它在人类历史中出现得很晚,在个体发育过程中也很晚才发展起来。衰老不会引起对复杂图像书写描述的词汇、语义和句法参数的变化。同样,拼写也不会因衰老而发生显著改变。老年人中拼写错误很少见:它们只涉及不常用的单词,并且大多遵循其发音。最常见的错误是关于重音或双字母。页边距变小,老年人提笔次数减少,书写的压力和宽度随年龄增长而减小。在阿尔茨海默病期间,书写会逐渐变得杂乱无章。文本内容首先受到影响,文本变得更短且连贯性更差。然后,拼写会因规则化错误而改变,这是词汇性失写症的一个迹象。接着,词汇性失写症会恶化并迅速变得混合,结合了词汇和语音特征。最后,痴呆症加剧,同时书写特征和空间组织大幅退化。阿尔茨海默病的失写症源于几个联合区域(即顶叶、颞叶、枕叶和额叶区域)的脑损伤导致的语言和书写各个组成部分的渐进性、分层性紊乱。

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