Maget-Dana R, Thimon L, Peypoux F, Ptak M
Centre de Biophysique Moléculaire, CNRS, Orléans, France.
Biochimie. 1992 Dec;74(12):1047-51. doi: 10.1016/0300-9084(92)90002-v.
Iturin A and surfactin are two lipopeptides extracted from a same strain of Bacillus subtilis. Iturin A possesses antibiotic and antifungal activities and surfactin is a strong surfactant. The presence of surfactin, at a concentration at which, alone, it is inactive, increases to a very large extent the haemolysis percent induced by iturin A. This synergistic effect seems to be in relation with interactions between iturin A and surfactin. Iturin A adsorbs to and penetrates into surfactin monolayers. Iturin A and surfactin are miscible and interact specifically in mixed monolayers.
伊枯草菌素A和表面活性素是从同一株枯草芽孢杆菌中提取的两种脂肽。伊枯草菌素A具有抗生素和抗真菌活性，而表面活性素是一种强力表面活性剂。单独存在时无活性的表面活性素，当其浓度存在时，会极大地增加伊枯草菌素A诱导的溶血百分比。这种协同效应似乎与伊枯草菌素A和表面活性素之间的相互作用有关。伊枯草菌素A吸附并渗透到表面活性素单分子层中。伊枯草菌素A和表面活性素可互溶，并在混合单分子层中发生特异性相互作用。
