Shukla Sunil Dutt, Bhatnagar Maheep, Khurana Sukant
Shri Bhogi Lal Pandya Government College Dungarpur, Rajasthan, India.
Front Neurosci. 2012 Jul 26;6:112. doi: 10.3389/fnins.2012.00112. eCollection 2012.
Oxidative damage caused by free radicals plays an important role in the causation and progression of many diseases, including aging. Free-radical damage is countered by many mechanisms, including both active antioxidant enzymatic activity in our body and passive antioxidants. Antioxidant response of our body can accommodate increased oxidative damage in diseased states to a level but beyond that level, additional antioxidants are required to combat the increased stress. Apart from the regular dietary sources of antioxidants, many traditional herbal medicines demonstrate a potential to boost antioxidant activity. Rasayana chikitsa that deals with rejuvenation and revitalization is a branch of the Indian traditional medical system of ayurveda. We review some select herbs described in rasayana chikitsa that have been assessed by modern means for stimulating intrinsic antioxidant responses in humans. A critical evaluation of rasayana chikitsa will likely provide urgently needed, actual stimulants of our physiological antioxidant responses and not just more passive antioxidants to add to an already large catalog.
自由基引起的氧化损伤在包括衰老在内的许多疾病的发生和发展中起着重要作用。自由基损伤可通过多种机制来对抗，包括我们体内的活性抗氧化酶活性和被动抗氧化剂。我们身体的抗氧化反应可以将患病状态下增加的氧化损伤调节到一定水平，但超过该水平后，就需要额外的抗氧化剂来对抗增加的压力。除了常规的饮食抗氧化剂来源外，许多传统草药也显示出增强抗氧化活性的潜力。rasayana chikitsa涉及恢复活力和振兴，是印度传统医学阿育吠陀体系的一个分支。我们回顾了rasayana chikitsa中描述的一些精选草药，这些草药已通过现代方法进行评估，以刺激人体内在的抗氧化反应。对rasayana chikitsa进行批判性评估可能会提供迫切需要的、真正刺激我们生理抗氧化反应的物质，而不仅仅是为已经庞大的目录增加更多被动抗氧化剂。
