Asilian A, Sadeghinia A, Faghihi G, Momeni A, Amini Harandi A
Department of Dermatology, St Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Ann Trop Med Parasitol. 2003 Jul;97(5):493-8. doi: 10.1179/000349803225001373.
It would be very useful to have a more effective and more rapid method available for the treatment of cutaneous leishmaniasis (CL). The main aim of the present, Iranian study, was to see if the combination of cryotherapy and intralesional injections with meglumine antimoniate (C + MA) would be more effective than the injections given alone (MA) or the combination of cryotherapy plus intralesional sodium stibogluconate (C + SS). Forty patients (with 67 lesions) were treated with C + MA, another 40 (with 65 lesions) were treated with C + SS and 100 patients (with 180 lesions) were treated with MA. Follow-up for 6 months after the final treatment indicated that 89.5% of the lesions treated with C + MA, 92.3% of those treated with C + SS but only 50% of the lesions treated with MA only were completely cured. The frequencies of cure in the two cryotherapy groups were similar, both being significantly higher than that in the MA group (P < 0.05). The combination of cryotherapy with intralesional injections of meglumine antimoniate or sodium stibogluconate, which is much more effective than the use of intralesional meglumine antimoniate alone, should be promoted.
拥有一种更有效、更快速的治疗皮肤利什曼病（CL）的方法将非常有用。目前这项伊朗研究的主要目的是探究冷冻疗法与葡甲胺锑酸盐病灶内注射联合使用（C + MA）是否比单独注射（MA）或冷冻疗法加病灶内注射葡萄糖酸锑钠（C + SS）更有效。40例患者（67个病灶）接受了C + MA治疗，另外40例（65个病灶）接受了C + SS治疗，100例患者（180个病灶）接受了MA治疗。最后一次治疗后随访6个月表明，接受C + MA治疗的病灶中有89.5%、接受C + SS治疗的病灶中有92.3%完全治愈，但仅接受MA治疗的病灶中只有50%完全治愈。两个冷冻疗法组的治愈率相似，均显著高于MA组（P < 0.05）。冷冻疗法与葡甲胺锑酸盐或葡萄糖酸锑钠病灶内注射联合使用比单独使用病灶内葡甲胺锑酸盐更有效，应予以推广。
