松杉灵芝子实体中的羊毛甾烷型三萜类化合物和三萜糖苷及其对COX-1和COX-2的抑制活性。

Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2.

作者信息

Yoshikawa Kazuko, Inoue Megumi, Matsumoto Yuki, Sakakibara Chika, Miyataka Hideki, Matsumoto Hitoshi, Arihara Shigenobu

机构信息

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-Cho, Tokushima 770-8514, Japan.

出版信息

J Nat Prod. 2005 Jan;68(1):69-73. doi: 10.1021/np040130b.

DOI:10.1021/np040130b

PMID:15679320

Abstract

Two new lanostane triterpenoids (1, 2) and 10 new lanostane triterpene glycosides (3-12) have been isolated from the fruit bodies of Fomitopsis pinicola. Their structures were established primarily by NMR experiments and chemical methods, and their biological activity against COX-1 and COX-2 was investigated.

摘要

从松木层孔菌子实体中分离出了两种新的羊毛甾烷三萜（1, 2）和10种新的羊毛甾烷三萜糖苷（3 - 12）。它们的结构主要通过核磁共振实验和化学方法确定，并研究了它们对COX - 1和COX - 2的生物活性。