College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
J Nat Prod. 2010 Feb 26;73(2):172-6. doi: 10.1021/np900578h.
Four new lanostane triterpenes, butyl ganoderate A (1), butyl ganoderate B (2), butyl lucidenate N (3), and butyl lucidenate A (4), were isolated from the fruiting bodies of Ganoderma lucidum together with 14 known compounds (5-18). The structures of the new triterpenes were established by extensive spectroscopic studies and chemical evidence. In addition, the inhibitory effect of isolated compounds on adipocyte differentiation in 3T3-L1 cells was examined.
四种新的羊毛甾烷三萜类化合物，丁基灵芝酸 A（1）、丁基灵芝酸 B（2）、丁基灵芝烯酸 N（3）和丁基灵芝烯酸 A（4），从灵芝的子实体中分离出来，同时还分离出了 14 种已知化合物（5-18）。新三萜类化合物的结构通过广泛的光谱研究和化学证据确定。此外，还检测了分离得到的化合物对 3T3-L1 细胞脂肪细胞分化的抑制作用。
