新型隐球菌的一种多糖脱乙酰酶诱导1型辅助性T细胞应答
Induction of T helper type 1 responses by a polysaccharide deacetylase from Cryptococcus neoformans.
作者信息
Biondo Carmelo, Beninati Concetta, Bombaci Mauro, Messina Luciano, Mancuso Giuseppe, Midiri Angelina, Galbo Roberta, Teti Giuseppe
机构信息
Dipartimento di Patologia e Microbiologia Sperimentale, Facoltà di Medicina e Chirurgia, Università di Messina, I-98125 Messina, Italy.
出版信息
Infect Immun. 2003 Sep;71(9):5412-7. doi: 10.1128/IAI.71.9.5412-5417.2003.
Abstract
A 25-kDa cryptococcal deacetylase (d25) was found here to induce cell proliferation, as well as secretion of interleukin 2 and gamma interferon, but not interleukin 4, in spleen cells from d25-immunized or Cryptococcus neoformans-infected mice. The gamma interferon, but not the interleukin 2, response was required for the protective activities of d25 immunization in a murine cryptococcosis model.
摘要
在此发现一种25 kDa的隐球菌脱乙酰酶（d25）可诱导来自经d25免疫或新型隐球菌感染小鼠的脾细胞发生细胞增殖，以及分泌白细胞介素2和γ干扰素，但不分泌白细胞介素4。在小鼠隐球菌病模型中，d25免疫的保护活性需要γ干扰素应答，但不需要白细胞介素2应答。
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本文引用的文献
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Induction of interleukin-12 and gamma interferon requires tumor necrosis factor alpha for protective T1-cell-mediated immunity to pulmonary Cryptococcus neoformans infection.诱导白细胞介素-12和γ干扰素需要肿瘤坏死因子α，以实现保护性T1细胞介导的针对肺部新型隐球菌感染的免疫反应。
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