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新型隐球菌的一种多糖脱乙酰酶诱导1型辅助性T细胞应答

Induction of T helper type 1 responses by a polysaccharide deacetylase from Cryptococcus neoformans.

作者信息

Biondo Carmelo, Beninati Concetta, Bombaci Mauro, Messina Luciano, Mancuso Giuseppe, Midiri Angelina, Galbo Roberta, Teti Giuseppe

机构信息

Dipartimento di Patologia e Microbiologia Sperimentale, Facoltà di Medicina e Chirurgia, Università di Messina, I-98125 Messina, Italy.

出版信息

Infect Immun. 2003 Sep;71(9):5412-7. doi: 10.1128/IAI.71.9.5412-5417.2003.

DOI:10.1128/IAI.71.9.5412-5417.2003
PMID:12933895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC187367/
Abstract

A 25-kDa cryptococcal deacetylase (d25) was found here to induce cell proliferation, as well as secretion of interleukin 2 and gamma interferon, but not interleukin 4, in spleen cells from d25-immunized or Cryptococcus neoformans-infected mice. The gamma interferon, but not the interleukin 2, response was required for the protective activities of d25 immunization in a murine cryptococcosis model.

摘要

在此发现一种25 kDa的隐球菌脱乙酰酶（d25）可诱导来自经d25免疫或新型隐球菌感染小鼠的脾细胞发生细胞增殖，以及分泌白细胞介素2和γ干扰素，但不分泌白细胞介素4。在小鼠隐球菌病模型中，d25免疫的保护活性需要γ干扰素应答，但不需要白细胞介素2应答。

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本文引用的文献

1
Purification and characterization of a second immunoreactive mannoprotein from Cryptococcus neoformans that stimulates T-Cell responses.新型隐球菌中第二种刺激T细胞反应的免疫反应性甘露糖蛋白的纯化与特性分析
Infect Immun. 2002 Oct;70(10):5485-93. doi: 10.1128/IAI.70.10.5485-5493.2002.
2
Induction of interleukin-12 and gamma interferon requires tumor necrosis factor alpha for protective T1-cell-mediated immunity to pulmonary Cryptococcus neoformans infection.诱导白细胞介素-12和γ干扰素需要肿瘤坏死因子α，以实现保护性T1细胞介导的针对肺部新型隐球菌感染的免疫反应。
Infect Immun. 2002 Jun;70(6):2959-64. doi: 10.1128/IAI.70.6.2959-2964.2002.
3
Identification and cloning of a cryptococcal deacetylase that produces protective immune responses.一种产生保护性免疫反应的隐球菌脱乙酰酶的鉴定与克隆。
Infect Immun. 2002 May;70(5):2383-91. doi: 10.1128/IAI.70.5.2383-2391.2002.
4
Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans.一种与几丁质脱乙酰酶具有同源性的甘露糖蛋白的分子特征，该蛋白可刺激T细胞对新型隐球菌的反应。
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10422-7. doi: 10.1073/pnas.181331398. Epub 2001 Aug 14.
5
The Cryptococcus neoformans gene DHA1 encodes an antigen that elicits a delayed-type hypersensitivity reaction in immune mice.新型隐球菌基因DHA1编码一种抗原，该抗原能在免疫小鼠中引发迟发型超敏反应。
Infect Immun. 2000 Nov;68(11):6196-201. doi: 10.1128/IAI.68.11.6196-6201.2000.
6
IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells.白细胞介素-18通过诱导自然杀伤细胞产生γ干扰素，在白细胞介素-12合成缺陷的小鼠中，有助于宿主抵抗新型隐球菌感染。
J Immunol. 2000 Jul 15;165(2):941-7. doi: 10.4049/jimmunol.165.2.941.
7
Interleukin-4 weakens host resistance to pulmonary and disseminated cryptococcal infection caused by combined treatment with interferon-gamma-inducing cytokines.白细胞介素-4会削弱宿主对由诱导γ-干扰素的细胞因子联合治疗所引发的肺部和播散性隐球菌感染的抵抗力。
Cell Immunol. 1999 Oct 10;197(1):55-61. doi: 10.1006/cimm.1999.1557.
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Role of IL-10 in a neonatal mouse listeriosis model.
J Immunol. 1999 Sep 1;163(5):2777-82.
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Infect Immun. 1998 Oct;66(10):4994-5000. doi: 10.1128/IAI.66.10.4994-5000.1998.
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Interleukin-15 induces antimicrobial activity after release by Cryptococcus neoformans-stimulated monocytes.新型隐球菌刺激单核细胞释放白细胞介素-15后可诱导抗菌活性。
J Infect Dis. 1998 Sep;178(3):803-14. doi: 10.1086/515381.