与表达Ma1、Ma2和Ma3 mRNA的乳腺癌相关的抗Ma2抗体相关副肿瘤性边缘叶/脑干脑炎。
Anti-Ma2 antibody related paraneoplastic limbic/brain stem encephalitis associated with breast cancer expressing Ma1, Ma2, and Ma3 mRNAs.
作者信息
Sahashi K, Sakai K, Mano K, Hirose G
机构信息
Department of Neurology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan.
出版信息
J Neurol Neurosurg Psychiatry. 2003 Sep;74(9):1332-5. doi: 10.1136/jnnp.74.9.1332.
A 69 year old woman presented with cognitive impairment and supranuclear gaze palsy caused by paraneoplastic limbic/brain stem encephalitis associated with atypical medullary breast carcinoma. The cerebrospinal fluid from the patient harboured an anti-neuronal cell antibody against Ma2 antigen, but not against Ma1 or Ma3 antigen. Despite the antibody being restricted to the Ma2 antigen, the patient's cancer tissue expressed Ma1, Ma2, and Ma3 mRNAs. These results, and the expression of Ma2 mRNA in an atypical medullar breast carcinoma in another patient without paraneoplastic encephalitis, indicate that the induction of anti-Ma2 antibody depends on host immunoreponsiveness and not on the presence of the antigen itself in the cancer.
一名69岁女性因副肿瘤性边缘叶/脑干脑炎合并非典型髓样乳腺癌出现认知障碍和核上性凝视麻痹。该患者的脑脊液中存在针对Ma2抗原的抗神经元细胞抗体，但不存在针对Ma1或Ma3抗原的抗体。尽管该抗体仅针对Ma2抗原，但患者的癌组织表达Ma1、Ma2和Ma3 mRNA。这些结果，以及另一名无副肿瘤性脑炎的患者的非典型髓样乳腺癌中Ma2 mRNA的表达，表明抗Ma2抗体的诱导取决于宿主免疫反应性，而非癌症中抗原本身的存在。
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