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抗Ma2抗体相关脑炎：一种非典型副肿瘤性神经系统综合征。

Anti-Ma2-antibody-associated encephalitis: An atypical paraneoplastic neurologic syndrome.

作者信息

Targonska Bogna, Frost Jamie, Prabhu Sanjay

机构信息

Department of Radiology, Renown Regional Medical Center, Reno, NV, United States.

Helen DeVos Childrens Hospital, Advanced Radiology Services, Grand Rapids, MI, United States.

出版信息

SA J Radiol. 2018 May 17;22(1):1310. doi: 10.4102/sajr.v22i1.1310. eCollection 2018.

DOI:10.4102/sajr.v22i1.1310
PMID:31754496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6837793/
Abstract

Paraneoplastic syndromes are a heterogeneous group of conditions affecting cancer patients, where the signs and symptoms are not owing to the local effects of the tumour but instead owing to humoral or immunologic effects. We describe an unusual presentation of a paraneoplastic neurologic syndrome presenting with predominant involvement of the hypothalamus and deep grey nuclei secondary to an anterior mediastinal germinoma and associated with anti-Ma2 antibody.

摘要

副肿瘤综合征是一组影响癌症患者的异质性疾病，其体征和症状并非由肿瘤的局部效应引起，而是由体液或免疫效应所致。我们描述了一例副肿瘤性神经综合征的不寻常表现，该综合征主要累及下丘脑和深部灰质核，继发于前纵隔生殖细胞瘤，并与抗Ma2抗体相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b7/6837793/e4700a7fd776/SAJR-22-1310-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b7/6837793/8a3c0493650c/SAJR-22-1310-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b7/6837793/92e840147e4c/SAJR-22-1310-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b7/6837793/4373644ccc6a/SAJR-22-1310-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b7/6837793/e4700a7fd776/SAJR-22-1310-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b7/6837793/8a3c0493650c/SAJR-22-1310-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b7/6837793/92e840147e4c/SAJR-22-1310-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b7/6837793/4373644ccc6a/SAJR-22-1310-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b7/6837793/e4700a7fd776/SAJR-22-1310-g004.jpg

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本文引用的文献

1
Are onconeural antibodies a clinical phenomenology in paraneoplastic limbic encephalitis?抗神经原抗体是否为副肿瘤性边缘性脑炎的临床现象学表现？
Mediators Inflamm. 2013;2013:172986. doi: 10.1155/2013/172986. Epub 2013 Jul 25.
2
Paraneoplastic syndromes: an approach to diagnosis and treatment.副肿瘤综合征：一种诊断和治疗方法。
Mayo Clin Proc. 2010 Sep;85(9):838-54. doi: 10.4065/mcp.2010.0099.
3
[Anti-Ma2-associated encephalitis and paraneoplastic limbic encephalitis].[抗Ma2相关脑炎和副肿瘤性边缘叶脑炎]
Brain Nerve. 2010 Aug;62(8):838-51.
4
Clinical analysis of anti-Ma2-associated encephalitis.抗Ma2相关脑炎的临床分析
Brain. 2004 Aug;127(Pt 8):1831-44. doi: 10.1093/brain/awh203. Epub 2004 Jun 23.
5
Paraneoplastic syndromes: when to suspect, how to confirm, and how to manage.副肿瘤综合征：何时怀疑、如何确诊以及如何处理。
J Neurol Neurosurg Psychiatry. 2004 Jun;75 Suppl 2(Suppl 2):ii43-50. doi: 10.1136/jnnp.2004.040378.
6
Anti-Ma2 antibody related paraneoplastic limbic/brain stem encephalitis associated with breast cancer expressing Ma1, Ma2, and Ma3 mRNAs.与表达Ma1、Ma2和Ma3 mRNA的乳腺癌相关的抗Ma2抗体相关副肿瘤性边缘叶/脑干脑炎。
J Neurol Neurosurg Psychiatry. 2003 Sep;74(9):1332-5. doi: 10.1136/jnnp.74.9.1332.