Wernz Cort, Pupa Lauren, Ossimetha Ashley, Ansari Sahifah, Moron Fanny
Radiology, Baylor College of Medicine, Houston, USA.
Cureus. 2023 Jun 22;15(6):e40816. doi: 10.7759/cureus.40816. eCollection 2023 Jun.
Anti-Ma2 encephalitis is a rare form of autoimmune encephalitis that has classically been described as a paraneoplastic neurobehavioral disorder due to its association with underlying malignancies. We discuss the case of a 30-year-old female with an exceptionally aggressive presentation of anti-Ma2 encephalitis accompanied by Klüver-Bucy syndrome and hypothalamic dysfunction. Her course was complicated by repeated aspiration events secondary to severe hyperphagia and delays in immunosuppressive treatment due to concerns of infection. The patient's encephalitis was refractory to multiple immunosuppressive therapies and she ultimately expired before a primary malignancy could be detected and treated.
抗Ma2脑炎是一种罕见的自身免疫性脑炎，由于其与潜在恶性肿瘤相关，传统上被描述为一种副肿瘤性神经行为障碍。我们讨论了一例30岁女性患者，其抗Ma2脑炎表现异常侵袭性，伴有克吕弗-布西综合征和下丘脑功能障碍。她的病程因严重贪食继发反复误吸事件以及因担心感染而延迟免疫抑制治疗而复杂化。患者的脑炎对多种免疫抑制治疗均无效，最终在原发性恶性肿瘤被检测和治疗之前死亡。
