Li Xifeng, Jeong Jee Hean, Lee Kang Tae, Rho Jung Rae, Choi Hong Dae, Kang Jung Sook, Son Byeng Wha
Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
Arch Pharm Res. 2003 Jul;26(7):532-4. doi: 10.1007/BF02976876.
Kojic acid dimethyl ether (1), and the known kojic acid monomethyl ether (2), kojic acid (3) and phomaligol A (4) have been isolated from the organic extract of the broth of the marine-derived fungus Alternaria sp. collected from the surface of the marine green alga Ulva pertusa. The structures were assigned on the basis of comprehensive spectroscopic analyses. Each isolate was tested for its tyrosinase inhibitory activity. Kojic acid (3) was found to have significant tyrosinase inhibitory activity, but compounds 1, 2, and 4 were found to be inactive.
从采集自海洋绿藻孔石莼表面的海洋来源真菌链格孢属菌株的发酵液有机提取物中分离得到了曲酸二甲醚（1）、已知的曲酸单甲醚（2）、曲酸（3）和phomaligol A（4）。通过综合光谱分析确定了其结构。对每种分离物进行了酪氨酸酶抑制活性测试。发现曲酸（3）具有显著的酪氨酸酶抑制活性，但化合物1、2和4无活性。
