Key Laboratory of Bio-Pesticide Innovation and Application of Guangdong Province, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China.
Molecules. 2021 Dec 21;27(1):18. doi: 10.3390/molecules27010018.
Fungi can synthesize a wealth of secondary metabolites, which are widely used in the exploration of lead compounds of pharmaceutical or agricultural importance. , , and are the most extensively studied fungi in which a large number of biologically active metabolites have been identified. However, relatively little attention has been paid to . are soil-habituated fungi that are widely distributed in nature and are very important biocontrol fungi in agriculture, providing good biological control of plant parasitic nematodes and having a significant effect on , , and . At the same time, it produces secondary metabolites with various biological activities such as anticancer, antimicrobial, and insecticidal. This review attempts to provide a comprehensive overview of the secondary metabolites of , with emphasis on the chemical diversity and biological activity of these secondary metabolites and the biosynthetic pathways, and gives new insight into the secondary metabolites of medical and entomogenous fungi, which is expected to provide a reference for the development of medicine and agrochemicals in the future.
真菌可以合成丰富的次生代谢产物,这些产物广泛应用于药物和农业领域的先导化合物的探索中。 、 和 是研究最为广泛的真菌,其中已经鉴定出大量具有生物活性的代谢产物。然而,相对较少关注 。 是适应土壤的真菌,广泛分布于自然界中,在农业中是非常重要的生物防治真菌,对植物寄生线虫具有良好的生物防治作用,并且对 、 和 具有显著的影响。同时,它还产生具有抗癌、抗菌和杀虫等各种生物活性的次生代谢产物。本文试图对 的次生代谢产物进行全面概述,重点介绍这些次生代谢产物的化学多样性和生物活性以及生物合成途径,并为药用和昆虫病原真菌的次生代谢产物提供新的见解,有望为未来的医药和农用化学品的开发提供参考。