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Measurement of cefaclor and amoxicillin-clavulanic acid levels in middle-ear fluid in patients with acute otitis media.急性中耳炎患者中耳积液中头孢克洛和阿莫西林-克拉维酸水平的测定。
Antimicrob Agents Chemother. 2003 Sep;47(9):2987-9. doi: 10.1128/AAC.47.9.2987-2989.2003.
2
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South Med J. 1990 Oct;83(10):1174-7. doi: 10.1097/00007611-199010000-00013.
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Comparison of cefprozil with other antibiotic regimens in the treatment of children with acute otitis media.头孢丙烯与其他抗生素治疗方案在儿童急性中耳炎治疗中的比较。
Clin Infect Dis. 1992 Jun;14 Suppl 2:S204-8; discussion S209-11. doi: 10.1093/clinids/14.supplement_2.s204.
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9
Penetration of amoxicillin, cefaclor, erythromycin-sulfisoxazole, and trimethoprim-sulfamethoxazole into the middle ear fluid of patients with chronic serous otitis media.阿莫西林、头孢克洛、红霉素 - 磺胺异恶唑及甲氧苄啶 - 磺胺甲恶唑在慢性浆液性中耳炎患者中耳液中的渗透情况。
J Infect Dis. 1982 Jun;145(6):815-21. doi: 10.1093/infdis/145.6.815.
10
Middle ear fluid concentrations of amoxicillin after large dosages in children with acute otitis media.大剂量阿莫西林治疗急性中耳炎患儿后中耳液中的药物浓度
Pediatr Infect Dis J. 1998 Oct;17(10):969-70. doi: 10.1097/00006454-199810000-00042.

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Clin Pharmacokinet. 2005;44(11):1097-115. doi: 10.2165/00003088-200544110-00001.

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Worldwide prevalence of antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the SENTRY Antimicrobial Surveillance Program, 1997-1999.1997 - 1999年哨兵抗菌监测项目中肺炎链球菌、流感嗜血杆菌和卡他莫拉菌的全球抗菌药物耐药性流行情况
Clin Infect Dis. 2001 May 15;32 Suppl 2:S81-93. doi: 10.1086/320181.
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Predicting the clinical efficacy of antibiotics: toward definitive criteria.预测抗生素的临床疗效：迈向明确标准
Pediatr Infect Dis J. 1997 Mar;16(3 Suppl):S56-9. doi: 10.1097/00006454-199703001-00006.
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Using antibiotic concentrations in middle ear fluid to predict potential clinical efficacy.
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Pharmacokinetics and pharmacodynamics of antibiotics in otitis media.抗生素在中耳炎中的药代动力学和药效学
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A new model examining intracellular and extracellular activity of amoxicillin, azithromycin, and clarithromycin in infected cells.一种研究阿莫西林、阿奇霉素和克拉霉素在受感染细胞内和细胞外活性的新模型。
Chemotherapy. 1993 Nov-Dec;39(6):416-23. doi: 10.1159/000238987.
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Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins.在确定广谱头孢菌素给药方案时药代动力学与药效学之间的相互关系。
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Antibiotic uptake by alveolar macrophages.肺泡巨噬细胞对抗生素的摄取。
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Uptake, accumulation, and egress of erythromycin by tissue culture cells of human origin.红霉素在人源组织培养细胞中的摄取、积累及排出。
Antimicrob Agents Chemother. 1985 Mar;27(3):314-9. doi: 10.1128/AAC.27.3.314.
9
Microbiology of recently treated acute otitis media compared with previously untreated acute otitis media.近期治疗的急性中耳炎与既往未治疗的急性中耳炎的微生物学比较。
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Rapid high performance liquid chromatographic assay of cephalosporins in biological fluids.生物流体中头孢菌素的快速高效液相色谱测定法。
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急性中耳炎患者中耳积液中头孢克洛和阿莫西林-克拉维酸水平的测定。

Measurement of cefaclor and amoxicillin-clavulanic acid levels in middle-ear fluid in patients with acute otitis media.

作者信息

Scaglione F, Caronzolo D, Pintucci J P, Fraschini F

机构信息

University of Milan, Milan, Italy.

出版信息

Antimicrob Agents Chemother. 2003 Sep;47(9):2987-9. doi: 10.1128/AAC.47.9.2987-2989.2003.

DOI:10.1128/AAC.47.9.2987-2989.2003
PMID:12937009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC182623/
Abstract

Concentrations of cefaclor (CFC) or amoxicillin-clavulanic acid (AMX/CA) in middle-ear fluid collected preserving the stability and clearing the cell contents has been compared to those obtained using the traditional method. Sixty-seven children with effusive otitis media were treated orally with CFC (20 mg/kg of body weight) or AMX/CA (20 mg/kg) (4:1 ratio). The concentrations in cell-free fluid (C-) appear higher than those in the total fluid (C+) (as assayed traditionally).

摘要

在保持稳定性并清除细胞内容物的情况下收集的中耳液中头孢克洛（CFC）或阿莫西林 - 克拉维酸（AMX/CA）的浓度，已与使用传统方法获得的浓度进行了比较。67名分泌性中耳炎患儿口服CFC（20毫克/千克体重）或AMX/CA（20毫克/千克）（比例为4:1）进行治疗。无细胞液（C-）中的浓度似乎高于传统检测的总液（C+）中的浓度。