利奈唑胺单独使用或与万古霉素联合使用治疗耐甲氧西林金黄色葡萄球菌所致实验性心内膜炎的疗效。
Efficacy of linezolid alone or in combination with vancomycin for treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus.
作者信息
Chiang Fu-Yu, Climo Michael
机构信息
Division of Infectious Disease, Virginia Commonwealth University Health Systemthe, Richmond, Virginia, USA.
出版信息
Antimicrob Agents Chemother. 2003 Sep;47(9):3002-4. doi: 10.1128/AAC.47.9.3002-3004.2003.
Abstract
The levels of effectiveness of linezolid, vancomycin, and the combination of linezolid and vancomycin were compared in the rabbit model of endocarditis caused by a clinical methicillin-resistant Staphylococcus aureus (MRSA) isolate. Vancomycin alone was more effective than either linezolid alone or the combination of linezolid and vancomycin for the treatment of endocarditis due to MRSA.
摘要
在由临床耐甲氧西林金黄色葡萄球菌（MRSA）分离株引起的心内膜炎兔模型中，比较了利奈唑胺、万古霉素以及利奈唑胺与万古霉素联合用药的有效性水平。单独使用万古霉素在治疗由MRSA引起的心内膜炎方面比单独使用利奈唑胺或利奈唑胺与万古霉素联合用药更有效。
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