Loutan L, Plancherel C, Soulier-Lauper M, Pascual M, Subilia L, Chevrolet J C, Unger P F, Grau G E
Department of Medicine, Hôpital Cantonal Universitaire de Genève, Switzerland.
Trop Med Parasitol. 1992 Dec;43(4):285-6.
The authors report on three cases of severe P. falciparum malaria successfully treated by iv quinine and exchange transfusion. Serum concentrations of Tumor Necrosis Factor (TNF) were determined before and during treatment. After an initial decrease, serum levels of TNF remained markedly elevated during the first 48 hours despite exchange transfusion. Though exchange transfusion accelerates the elimination of parasites from the blood, it seems to have no immediate effects on reducing serum levels of cytokines such as TNF.
作者报告了3例通过静脉注射奎宁和换血成功治疗的严重恶性疟原虫疟疾病例。在治疗前和治疗期间测定了肿瘤坏死因子（TNF）的血清浓度。尽管进行了换血，但在最初下降后，TNF的血清水平在头48小时内仍显著升高。虽然换血可加速从血液中清除寄生虫，但它似乎对降低TNF等细胞因子的血清水平没有直接作用。
