Chuncharunee S, Jootar S, Leelasiri A, Archararit N, Prayoonwiwat W, Mongkonsritragoon W, Polvicha P, Srichaikul T
Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 1997 Sep;80 Suppl 1:S72-5.
Concentrations of tumor necrosis factor alpha (TNF-alpha) in serum were measured in 17 Thai men infected with Plasmodium falciparum malarial infections to determine whether they were affected by severity of infections or exchange transfusions. Twelve patients were considered having complicated malarial infections, eight of whom had cerebral malaria. Five patients had uncomplicated malarial infections. The results showed that malarial infection markedly raised TNF-alpha level above normal values (mean +/- SEM 406 +/- 38 vs 15 +/- 5, p = 0.004). In complicated malaria, cerebral involvement appeared to significantly increase concentration of TNF-alpha when compared to values in uncomplicated malaria (mean +/- SEM 496 +/- 64 vs 339 +/- 12, p = 0.01). Degree of parasitemia, intravenous quinine (day 0 value vs day 7 value) and exchange transfusion did not significantly affect TNF-alpha levels.
Serum level of TNF-alpha is increased in Plasmodium falciparum malarial infections and may be a useful index to predict severity of malarial infection, cerebral malaria in particular.
对17名感染恶性疟原虫疟疾的泰国男性进行血清中肿瘤坏死因子α（TNF-α）浓度测定，以确定其是否受感染严重程度或换血疗法的影响。12名患者被认为患有复杂疟疾感染，其中8人患有脑型疟疾。5名患者患有非复杂疟疾感染。结果显示，疟疾感染使TNF-α水平显著高于正常值（平均值±标准误 406±38 对比 15±5，p = 0.004）。在复杂疟疾中，与非复杂疟疾相比，脑部受累似乎显著增加了TNF-α浓度（平均值±标准误 496±64 对比 339±12，p = 0.01）。疟原虫血症程度、静脉注射奎宁（第0天值对比第7天值）和换血疗法对TNF-α水平无显著影响。
恶性疟原虫疟疾感染时血清TNF-α水平升高，可能是预测疟疾感染严重程度，尤其是脑型疟疾的有用指标。
