人类嗜T淋巴细胞病毒I/II与献血者：低风险人群中血清阳性的相关决定因素
HTLV-I/II and blood donors: determinants associated with seropositivity in a low risk population.
作者信息
Soares Bernadette Catalan, Proietti Anna Bãrbara de F Carneiro, Proietti Fernando Augusto
机构信息
Fundação Hemominas, Belo Horizonte, MG, Brasil.
出版信息
Rev Saude Publica. 2003 Aug;37(4):470-6. doi: 10.1590/s0034-89102003000400012. Epub 2003 Aug 20.
OBJECTIVE
Blood donors in Brazil have been routinely screened for HTLV-I/II since 1993. A study was performed to estimate the prevalence of HTLV-I/II infection in a low risk population and to better understand determinants associated with seropositivity.
METHODS
HTLV-I/II seropositive (n=135), indeterminate (n=167) and seronegative blood donors (n=116) were enrolled in an open prevalence prospective cohort study. A cross-sectional epidemiological study of positive, indeterminate and seronegative HTLV-I/II subjects was conducted to assess behavioral and environmental risk factors for seropositivity. HTLV-I/II serological status was confirmed using enzyme-linked immunosorbent assay (EIA) and Western blot (WB).
RESULTS
The three groups were not homogeneous. HTLV-I/II seropositivity was associated to past blood transfusion and years of schooling, a marker of socioeconomic status, and use of non-intravenous illegal drugs.
CONCLUSIONS
The study results reinforce the importance of continuous monitoring and improvement of blood donor selection process.
目的
自1993年以来，巴西的献血者一直在接受HTLV-I/II的常规筛查。开展了一项研究，以估计低风险人群中HTLV-I/II感染的患病率，并更好地了解与血清阳性相关的决定因素。
方法
将HTLV-I/II血清阳性（n=135）、不确定（n=167）和血清阴性的献血者（n=116）纳入一项开放性患病率前瞻性队列研究。对HTLV-I/II阳性、不确定和血清阴性的受试者进行横断面流行病学研究，以评估血清阳性的行为和环境风险因素。使用酶联免疫吸附测定（EIA）和蛋白质印迹法（WB）确认HTLV-I/II血清学状态。
结果
这三组并不具有同质性。HTLV-I/II血清阳性与既往输血、受教育年限（社会经济地位的一个指标）以及使用非静脉注射非法药物有关。
结论
研究结果强化了持续监测和改进献血者选择过程的重要性。
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