Rozman C, Reverter J C, Feliu E, Rozman M, Climent C, Berga L
Escuela Profesional de Hematología Farreras Valenti, Hospital Clínco y Provincial, Universidad de Barcelona.
Sangre (Barc). 1992 Oct;37(5):369-73.
The material was made up of 15 specimens of bone marrow biopsy with markedly heterogeneous distribution of fat tissue, alternating normal or hyperplastic zones (area I) with aplastic ones (area II). The method of study was the stereological technique on plastic-embedded specimen sections.
In the area II, with a fat tissue fraction markedly higher than in area I, both adipocyte number and size were significatively increased. The fat tissue fraction difference (Dif FRGR) between both areas was significatively correlated with the difference of the adipocytes number (Dif Nv) but not of the size (Dif D). However, in multiple regression both Dif Nv and Dif D contributed significatively to Dif FRGR.
Since the histopathological pattern investigated in this work represents a model caused by intervention of local factors, it can be concluded that these can modify both the size and number of adipocytes.
1）分析人类骨髓中脂肪组织部分分布不均的程度取决于脂肪细胞的大小和数量。2）推断局部因素对上述两个参数的影响。
材料由15份骨髓活检标本组成，脂肪组织分布明显不均，正常或增生区域（I区）与再生障碍区域（II区）交替出现。研究方法是对塑料包埋标本切片进行体视学技术。
在II区，脂肪组织部分明显高于I区，脂肪细胞数量和大小均显著增加。两个区域之间的脂肪组织部分差异（Dif FRGR）与脂肪细胞数量差异（Dif Nv）显著相关，但与大小差异（Dif D）无关。然而，在多元回归中，Dif Nv和Dif D均对Dif FRGR有显著贡献。
由于本研究中所研究的组织病理学模式代表了由局部因素干预引起的模型，因此可以得出结论，这些因素可以改变脂肪细胞的大小和数量。
