Rozman C, Reverter J C, Feliu E, Rozman M, Climent C, Berga L
Escuela de Hematología Farreras Valenti, Hospital Clínic, Universidad de Barcelona.
Sangre (Barc). 1993 Jun;38(3):217-20.
To assess whether the variations in the number and size of the adipocytes are proportional, or not, to the changes of the fat tissue fraction (FF) associated to different degrees of hematopoietic cellularity of the bone-marrow.
The material was made up of 28 specimens of bone marrow biopsy, from which 265 microscopic fields representing a wide range of FF were obtained. As index of proportionality, the ratio N/S (adipocyte number/size) was employed.
The parameters FF and N/S showed a highly significant correlation (r = 0.89; p = 0.00000003) at low-normal FF range (< 40%), whereas at high FF range (> 40%), such a correlation was lacking (r = 0.01; p = 0.86).
At low-normal FF the adipocyte number and size vary proportionally. Conversely, at high FF, in some cases a more marked increase of number and in other instances of adipocyte size is detected. Further investigations are needed to find out the responsible factors for this different behaviour.
评估脂肪细胞数量和大小的变化是否与骨髓造血细胞不同程度相关的脂肪组织分数（FF）的变化成比例。
材料由28例骨髓活检标本组成，从中获得了265个代表广泛FF范围的显微镜视野。使用N/S（脂肪细胞数量/大小）比值作为比例指标。
在低正常FF范围（<40%）时，参数FF和N/S显示出高度显著的相关性（r = 0.89；p = 0.00000003），而在高FF范围（>40%）时，缺乏这种相关性（r = 0.01；p = 0.86）。
在低正常FF时，脂肪细胞数量和大小成比例变化。相反，在高FF时，在某些情况下检测到数量更明显增加，而在其他情况下检测到脂肪细胞大小增加。需要进一步研究以找出导致这种不同行为的因素。
