Rozman C, Feliu E, Berga L, Reverter J C, Climent C, Ferrán M J
Postgraduate School of Haematology Farreras Valenti, Hospital Clínic, University of Barcelona, Spain.
Exp Hematol. 1989 Jan;17(1):34-7.
Studies dealing with the number or size of individual adipose cells in human bone marrow are lacking. To ascertain whether the age-related variations in fat tissue fraction depend on the size of individual adipocytes or their number or both, a stereological study of 20 normal human bone marrow specimens was performed. A total number of 17,039 adipose cell profiles was measured and two stereological parameters were obtained in each specimen: mean diameter and number of cells per mm3 of bone marrow. With increasing age, an increasing fat tissue fraction was observed (r = 0.61; p = 0.004). The fat tissue fraction correlated positively with the size (r = 0.81; p less than 0.001) and the number/volume (r = 0.59; p = 0.006) of adipocytes. The significance of both adipocyte size and adipocyte number/volume was confirmed by stepwise multiple regression, in which the size alone explained 66.2% of fat tissue fraction and both size and number/volume explained 97.2% of fat tissue fraction. These results are discussed from a pathophysiological point of view.
关于人类骨髓中单个脂肪细胞数量或大小的研究尚属空白。为了确定脂肪组织比例随年龄的变化是取决于单个脂肪细胞的大小、数量还是两者皆有，我们对20份正常人类骨髓标本进行了体视学研究。共测量了17,039个脂肪细胞剖面，并在每个标本中获得了两个体视学参数：平均直径和每立方毫米骨髓中的细胞数量。随着年龄的增长，脂肪组织比例呈上升趋势（r = 0.61；p = 0.004）。脂肪组织比例与脂肪细胞大小（r = 0.81；p < 0.001）以及数量/体积（r = 0.59；p = 0.006）呈正相关。通过逐步多元回归证实了脂肪细胞大小和数量/体积两者的重要性，其中仅大小一项就解释了脂肪组织比例的66.2%，大小和数量/体积共同解释了脂肪组织比例的97.2%。我们从病理生理学角度对这些结果进行了讨论。
