Creutzig H
Rofo. 1975 Oct;123(4):313-8. doi: 10.1055/s-0029-1230204.
Renal and extra-renal clearance of 18F and 99mTc-EHDP were compared in the same individuals. The 18F space is twice that of 99mTc-EHDP, as is its renal clearance. 99mTc undergoes glomerular filtration, 18F is excreted by glomerular filtration and tubular secretion. Extraction rate was determined indirectly by a comparison with extra-renal clearance, and for patients without bone disease it was four times as high for 18F as it was for 99mTc-EHDP. In patients with secondary hyperparathyroidism extra-renal clearance is greatly increased. This is explained by an increased extraction rate, which may be different for the two substances.
在同一批个体中比较了¹⁸F和⁹⁹ᵐTc-EHDP的肾清除率和肾外清除率。¹⁸F的分布容积是⁹⁹ᵐTc-EHDP的两倍，其肾清除率也是如此。⁹⁹ᵐTc通过肾小球滤过，¹⁸F通过肾小球滤过和肾小管分泌排泄。通过与肾外清除率比较间接测定摄取率，对于无骨病的患者，¹⁸F的摄取率是⁹⁹ᵐTc-EHDP的四倍。在继发性甲状旁腺功能亢进患者中，肾外清除率大大增加。这可以通过摄取率增加来解释，两种物质的摄取率可能不同。
