[对霉菌过敏原过敏作为变应性鼻炎患者支气管哮喘的危险因素]

[Allergy to mould allergens as a risk factor for bronchial asthma in patients suffering from allergic rhinitis].

作者信息

Bogacka Ewa, Nittner-Marszalska Marita, Fal Andrzej M, Kuzniar Jolanta, Nikiel Elzbieta, Małolepszy Józef

机构信息

Klinika Chorób Wewnetrznych i Alergologii Akademii Medycznej we Wrocławiu.

出版信息

Pol Merkur Lekarski. 2003 May;14(83):388-92.

PMID:12939809

Abstract

UNLABELLED

The ARIA study demonstrates the correlation between bronchial asthma (BA) and perennial rhinitis (PR) with mite or animal fur allergies. There are no reports concerning correlation between BA and PR with mould allergy. The authors of this study estimated the prevalence of BA in patients with PR, allergic to moulds in comparison with patients allergic to other aeroallergens. 460 patients suffering from PR were investigated: 102 were allergic to moulds (mono- or multisensitization type) and 358 were allergic to other allergens. The prevalence of BA in mould-sensitive and insensitive patients was 70.6% and 43.6%, respectively; it was significantly higher in the mould-sensitive group (p = 0.004) regardless of the type of mould hypersensitivity (mono- or multisensitization). The higher prevalence of BA in mould-sensitive patients was found to be valid only for adults. The adult PR patients with diagnosed BA were most frequently allergic to Alternaria (47.1%) and Cladosporium (30.8%).

IN CONCLUSION

mould allergy may be a risk factor for BA development.

摘要

未标注

ARIA研究表明支气管哮喘（BA）与对螨虫或动物皮毛过敏的常年性鼻炎（PR）之间存在相关性。尚无关于BA与对霉菌过敏的PR之间相关性的报道。本研究的作者评估了与对其他空气过敏原过敏的患者相比，对霉菌过敏的PR患者中BA的患病率。对460例PR患者进行了调查：102例对霉菌过敏（单一或多敏化类型），358例对其他过敏原过敏。对霉菌敏感和不敏感患者中BA的患病率分别为70.6%和43.6%；无论霉菌超敏反应的类型（单一或多敏化）如何，霉菌敏感组中的患病率显著更高（p = 0.004）。发现霉菌敏感患者中BA的较高患病率仅在成人中成立。确诊为BA的成年PR患者最常对链格孢属（47.1%）和枝孢属（30.8%）过敏。