Semeniuk Janusz, Kaczmarski Maciej, Krasnow Aleksander, Sidor Katarzyna, Matuszewska Elzbieta, Daniluk Urszula
III Klinika Chorób Dzieci Akademii Medycznej, Samodzielny Publiczny Szpital Kliniczny w Białymstoku.
Pol Merkur Lekarski. 2003 May;14(83):405-9.
The aim of the current study was to analyse selected parameters of pH monitoring in the proximal and distal parts of esophagus. One hundred and twelve infants aged 1.25 to 18 months (mean = 5.6) with symptoms and signs suggesting gastroesophageal reflux (GER) were evaluated. The results are presented of the measurement of reflux index (RI), the number of reflux episodes and the duration of the longest reflux episode in patients classified into the following groups: group I--39 children with vomiting/excessive regurgitation, group II--29 infants with persistent distress/inconsolable crying, group III--16 children with Apparent Life Threatening Events (ALTE), group IV--28 infants with chronic/recurrent respiratory system diseases. No statistically significant difference was noted between the groups in pH parameters at the distal esophageal level, whereas at the proximal level the differences included only the number of reflux episodes. However, we found, that by using the ANOVA test, the incidence was higher in group IV than in group II. As determined by applying Mann-Whitney rank sum test, reflux episodes occurred most frequently in group IV, than in other groups of patients (including controls). None of the reflux parameters recorded at the proximal level among children presenting with ALTE was statistically significantly different than in other groups.
本研究的目的是分析食管近端和远端pH监测的选定参数。对112名年龄在1.25至18个月(平均 = 5.6岁)、有提示胃食管反流(GER)症状和体征的婴儿进行了评估。以下是对分为以下几组的患者的反流指数(RI)、反流发作次数和最长反流发作持续时间的测量结果:第一组——39名有呕吐/过度反流的儿童,第二组——29名有持续性烦躁/无法安抚的哭闹的婴儿,第三组——16名有明显危及生命事件(ALTE)的儿童,第四组——28名有慢性/复发性呼吸系统疾病的婴儿。在食管远端水平的pH参数方面,各组之间未发现统计学上的显著差异,而在近端水平,差异仅包括反流发作次数。然而,我们发现,通过方差分析测试,第四组的发生率高于第二组。通过应用曼-惠特尼秩和检验确定,第四组的反流发作比其他患者组(包括对照组)更频繁。在出现ALTE的儿童中,近端水平记录的反流参数与其他组相比均无统计学上的显著差异。