Watanabe Y, Fujiwara Y, Shiba M, Watanabe T, Tominaga K, Oshitani N, Matsumoto T, Nishikawa H, Higuchi K, Arakawa T
Dept. of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Scand J Gastroenterol. 2003 Aug;38(8):807-11. doi: 10.1080/00365520310004506.
Associations between lifestyle factors and gastro-oesophageal reflux disease (GORD) have been conflicting. We aimed to examine these associations in Japanese men.
We performed a cross-sectional study of Japanese male workers who visit a clinic for a routine health check-up and asked them to fill out a self-report questionnaire. Logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI) for GORD, defined as heartburn and/or acid regurgitation at least twice weekly.
Of the 4095 eligible subjects, 276 (6.7%) were diagnosed as having GORD. Current smoking was significantly associated with CORD compared with non-smoking (OR = 1.35, 95% CI, 1.01-1.82). Moderate drinking (16-37 mL/day) and heavy drinking (> or = 38 mL/day) were also associated with GORD, while age and body mass index were not. After adjustment for age, daily alcohol consumption and body mass index, an increase in number of pack-years of cigarette smoking was significantly associated with an increased OR of GORD (P for trend = 0.034), and the OR for persons whose number of pack-years of cigarette smoking was more than 20.1 was 1.45 (CI 1.04-2.04) compared with non-smokers.
Cigarette smoking and alcohol consumption are associated with an increased odds ratio for GORD in Japanese men.
生活方式因素与胃食管反流病（GORD）之间的关联一直存在争议。我们旨在研究日本男性中的这些关联。
我们对到诊所进行常规健康检查的日本男性工人进行了一项横断面研究，并要求他们填写一份自我报告问卷。采用逻辑回归计算胃食管反流病（定义为每周至少出现两次烧心和/或反酸）的比值比（OR）及95%置信区间（CI）。
在4095名符合条件的受试者中，276人（6.7%）被诊断为患有胃食管反流病。与不吸烟相比，当前吸烟与胃食管反流病显著相关（OR = 1.35，95% CI，1.01 - 1.82）。中度饮酒（每天16 - 37毫升）和重度饮酒（每天≥38毫升）也与胃食管反流病有关，而年龄和体重指数则无关。在对年龄、每日酒精摄入量和体重指数进行调整后，吸烟包年数的增加与胃食管反流病的OR增加显著相关（趋势P值 = 0.034），与不吸烟者相比，吸烟包年数超过20.1的人的OR为1.45（CI 1.04 - 2.04）。
在日本男性中，吸烟和饮酒与胃食管反流病的比值比增加有关。
