Marczinski Cecile A, Fillmore Mark T
Department of Psychology, University of Kentucky, Lexington 40506-0044, USA.
Exp Clin Psychopharmacol. 2003 Aug;11(3):228-36. doi: 10.1037/1064-1297.11.3.228.
The present study examined the separate and combined effects of alcohol and caffeine on behavioral control in a context in which preliminary cues signaled the likelihood that a response should be executed or inhibited. Social drinkers (N = 12) performed a cued go/no-go task that measured control as the quick execution of responses to go targets and sudden suppression of responses to no-go targets. Performance was tested under 3 doses of caffeine (0.0 mg/kg, 2.0 mg/kg, and 4.0 mg/kg) in combination with 2 doses of alcohol (0.0 g/kg and 0.65 g/kg). Alcohol impaired both inhibitory and activational aspects of behavioral control. Caffeine antagonized alcohol effects on response execution but had no effect on inhibitory control. The findings highlight potential differences in how activational and inhibitory aspects of behavioral control respond to drug interactions.
本研究考察了酒精和咖啡因在初步线索表明应执行或抑制反应可能性的情境中对行为控制的单独及联合作用。社交饮酒者（N = 12）完成了一项线索提示的停止信号任务，该任务将对执行目标的快速反应和对停止目标反应的突然抑制作为行为控制的衡量指标。在3种咖啡因剂量（0.0毫克/千克、2.0毫克/千克和4.0毫克/千克）与2种酒精剂量（0.0克/千克和0.65克/千克）组合的情况下对表现进行了测试。酒精损害了行为控制的抑制和激活两个方面。咖啡因拮抗了酒精对反应执行的影响，但对抑制控制没有影响。这些发现凸显了行为控制的激活和抑制方面对药物相互作用反应的潜在差异。
