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转基因植物中的维生素生产。

Vitamin production in transgenic plants.

作者信息

Herbers Karin

机构信息

SunGene GmbH & Co. KGaA, Corrensstr. 3, D-06466 Gatersleben, Germany.

出版信息

J Plant Physiol. 2003 Jul;160(7):821-9. doi: 10.1078/0176-1617-01024.

Abstract

Plants are a major source of vitamins in the human diet. Due to their significance for human health and development, research has been initiated to understand the biosynthesis of vitamins in plants. The pathways that are furthest advanced in elucidation are those of provitamin A, vitamin C and vitamin E. There is little knowledge about the regulation, storage, sink and degradation of any vitamin made in plants, or the interaction of vitamin biosynthetic pathways with other metabolic pathways. Researchers as well as life science companies have endeavoured to manipulate levels of vitamins in order to create functional food with enhanced health benefits, and even with the goal of achieving levels worth extracting from plant tissues. Thus far, metabolic engineering has resulted in transgenic plants that contain elevated levels of provitamin A, vitamin C and E, respectively. Additional research is necessary to identify all relevant target genes in order to further improve and tailor plants with elevated vitamin contents at will.

摘要

植物是人类饮食中维生素的主要来源。由于它们对人类健康和发育具有重要意义,人们已开展研究以了解植物中维生素的生物合成。在阐明过程中进展最为深入的途径是维生素A原、维生素C和维生素E的合成途径。对于植物中合成的任何维生素的调节、储存、库和降解,或者维生素生物合成途径与其他代谢途径的相互作用,人们了解甚少。研究人员和生命科学公司都致力于调控维生素水平,以创造具有更高健康益处的功能性食品,甚至目标是达到值得从植物组织中提取的水平。到目前为止,代谢工程已培育出分别含有高水平维生素A原、维生素C和维生素E的转基因植物。为了进一步随意改进和定制维生素含量升高的植物,有必要进行更多研究以确定所有相关的靶基因。

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